Publication highlights:
Perinatal dysfunction of innate immunity incystic fibrosis
Acid tolerance of Coxiella burnetii is strain-specific and might depend on stomach content.
Sobotta K, Schulze-Luehrmann J, Ölke M, Boden K, Lührmann A.
Pathogens (2025) 14: 272; doi: 10.3390/pathogens14030272
A novel inhibitor against the bromodomain protein 1 (PfBDP1) of the malaria pathogen Plasmodium falciparum.
Amann M, Warstat R, Rechten KK, Theuer P, Schustereder M, Clavey S, Breit B, Einsle O, Huegle M, Petter M, Guenther S.
ChemMedChem. 2025, accepted for publication. BioRxiv: doi: 10.1101/2025.01.16.633141.
PfGCN5 is essential for Plasmodium falciparum survival and transmission and regulates Pf H2B.Z acetylation and chromatin structure.
Tang J**, Yeoh LM**, Grotz MD**, Goodman CD, Chisholm SA, Nguyen HHT, Yu C, Pareek K, McPherson F, Cozijnsen A, Hustadt SA, Josling GA, Day KP, Schulz D, MacFadden GI, de Koning Ward TF*, Petter M, Duffy MF* (**co-first authors, *co-senior authors)
Nucleic Acids Research. 2025, doi: 10.1093/nar/gkaf218.
Eosinophils as modulators of host defense during parasitic, fungal, bacterial, and viral infections
The histone methyltransferase DOT1B is dispensable for stage differentiation and macrophage infection of Leishmania mexicana
Divergent effects of itaconate isomers on Coxiella burnetii growth in macrophages and in axenic culture
Md Nur A Alam Siddique, Fabian Kellermeier, Martha Ölke, Mingming Zhao, Konrad Büssow, Peter J. Oefner, Anja Lührmann, Katja Dettmer and Roland Lang.
Cell type-specific modulation of metabolic, immune-regulatory, and anti-microbial pathways by CD101
Marius Wrage, Tim Holland, BjörnNüse, Johanna Kaltwasser, Jessica Fröhlich, Harald Arnold, Claudia Gießler, Cindy Flamann, Heiko Bruns, Johannes Berges, Christoph Daniel, Markus H. Hoffmann, Chakkumkal Anish, Peter H. Seeberger, Christian Bogdan, Katja Dettmer, Manfred Rauh and Jochen Mattner.
Blockade of the CD47/SIRPα checkpoint axis potentiates the macrophage-mediated anti-tumor efficacy of tafasitamab.
Alexander Biedermann, Maria Patra-Kneuer, Dimitrios Mougiakakos, Maike Büttner-Herold, Doris Mangelberger-Eberl, Johannes Berges, Christian Kellner, Sarah Altmeyer, Jörg Thomas Bittenbring, Christian Augsberger, Kristina Ilieva-Babinsky, Stefan Haskamp, Fabian Beier, Christopher Lischer, Julio Vera, Anja Lührmann, Simone Bertz, Simon Völkl, Benedikt Jacobs, Stefan Steidl, Andreas Mackensen, Heiko Bruns.
Haematologica. 2024 Jun 27. doi: 10.3324/haematol.2023.284795.
Gene network-based and ensemble modeling-based selection of tumor-associated antigens with a predicted low risk of tissue damage for targeted immunotherapy.
Christopher Lischer, Martin Eberhardt, Johannes Berges, Cindy Flamann, Esther Güse, Anja Wessely, Adrian Weich, Jimmy Retzlaff, Jan Dörrie , Niels Schaft, Manuel Wiesinger, Johannes März, Beatrice Schuler- Thurner, Harald Knorr, Shailendra Gupta, Krishna Pal Singh, Gerold Schuler, Markus Vincent Heppt, Elias Andreas Thomas Koch, Nadine D van Kleef, Julian J Freen- van Heeren, Annelies W Turksma, Olaf Wolkenhauer, Bettina Hohberger, Carola Berking, Heiko Bruns, Julio Vera.
Eosinophils preserve bone homeostasis by inhibiting excessive osteoclast formation and activity via eosinophil peroxidase.
Nat Commun. 2024 Feb 5;15(1):1067. doi: 10.1038/s41467-024-45261-8. PubMed PMID: 38316791
L-arginine metabolism inhibits arthritis and inflammatory bone loss.
Shan Cao, Yixuan, Rui Song, Xianyi Meng, Maximilian Fuchs, Chunguang Liang, Katerina Kachler, Xinyu Meng, Jinming Wen, Ursula Schlötzer-Schrehardt, Verena Taudte, Arne Gessner, Meik Kunz, Ulrike Schleicher, Mario M Zaiss, Alf Kastbom, Xiaoxiang Chen, Georg Schett and Aline Bozec.
Ann Rheum Dis. 2024 Jan 2;83(1):72-87. doi: 10.1136/ard-2022-223626. PubMed PMID: 37775153
Acetate, a metabolic product of Heligmosomoides polygyrus, facilitates intestinal epithelial barrier breakdown in a FFAR2-dependent manner.
Int. J. Parasitol. 2022 Aug;52(9):591-601. doi: 10.1016/j.ijpara.2022.04.004. Epub 2022 Jun 6
High-fat-diet-associated intestinal microbiota exacerbates psoriasis-like inflammation by enhancing systemic γδ T cell IL-17 production.
Koshiro Sonomoto, Rui Song, Daniel Eriksson, Anne M Hahn, Xianyi Meng, Pang Lyu, Shan Cao, Ning Liu, R Verena Taudte, Stefan Wirtz, Yoshiya Tanaka, Thomas H Winkler, Georg Schett, Didier Soulat and Aline Bozec.
Chronic Systemic Infection of Mice with Leishmania infantum Leads to Increased Bone Mass
Chaobo Lai, Jennifer Heinemann, Ulrike Schleicher, Georg Schett, Christian Bogdan, Aline Bozec and Didier Soulat.
J Bone Miner Res. 2023 Jan;38(1):86-102. doi: 10.1002/jbmr.4733. Epub 2022 Nov 16
Acidic Microenvironments Found in Cutaneous Leishmania Lesions Curtail NO-Dependent Antiparasitic Macrophage Activity.