Latest Publications

Eosinophils preserve bone homeostasis by inhibiting excessive osteoclast formation and activity via eosinophil peroxidase.

Darja Andreev, Katerina Kachler, Mengdan Liu, Zhu Chen, Brenda Krishnacoumar, Mark Ringer, Silke Frey, Gerhard Krönke, David Voehringer, Georg Schett and Aline Bozec.

Nat Commun. 2024 Feb 5;15(1):1067. doi: 10.1038/s41467-024-45261-8. PubMed PMID: 38316791

L-arginine metabolism inhibits arthritis and inflammatory bone loss.

Shan Cao, Yixuan, Rui Song, Xianyi Meng, Maximilian Fuchs, Chunguang Liang, Katerina Kachler, Xinyu Meng, Jinming Wen, Ursula Schlötzer-Schrehardt, Verena Taudte, Arne Gessner, Meik Kunz, Ulrike Schleicher, Mario M Zaiss, Alf Kastbom, Xiaoxiang Chen, Georg Schett and Aline Bozec.

Ann Rheum Dis. 2024 Jan 2;83(1):72-87. doi: 10.1136/ard-2022-223626. PubMed PMID: 37775153

Acetate, a metabolic product of Heligmosomoides polygyrus, facilitates intestinal epithelial barrier breakdown in a FFAR2-dependent manner.

Fabian Schälter, Michael Frech, Kerstin Dürholz, Sébastien Lucas, Kerstin Sarter, Luc Lebon, Julia Esser-von Bieren, Lalit K Dubey, David Voehringer, Georg Schett, Nicola L Harris and Mario M. Zaiss. 

Int. J. Parasitol. 2022 Aug;52(9):591-601. doi: 10.1016/j.ijpara.2022.04.004. Epub 2022 Jun 6

High-fat-diet-associated intestinal microbiota exacerbates psoriasis-like inflammation by enhancing systemic γδ T cell IL-17 production.

Koshiro Sonomoto, Rui Song, Daniel Eriksson, Anne M Hahn, Xianyi Meng, Pang Lyu, Shan Cao, Ning Liu, R Verena Taudte, Stefan Wirtz, Yoshiya Tanaka, Thomas H Winkler, Georg Schett, Didier Soulat and Aline Bozec.