List of publications by doctoral researchers of the RTG 2740 (2022-2025)

2025

  • Tang J, Yeoh LM, Grotz MD, Goodman CD, Chisholm SA, Nguyen HHT, Yu C, Pareek K, McPherson F, Cozijnsen A, Hustadt SA, Josling GA, Day KP, Schulz D, MacFadden GI, de Koning Ward TF, Petter M, Duffy MF (2025). PfGCN5 is essential for Plasmodium falciparum survival and transmission and regulates Pf H2B.Z acetylation and chromatin structure. Nucleic Acids Res. doi: 10.1093/nar/gkaf218.
  • Flamann, C.S., Shaikh, H., Matos, C., Kreutz, M., Ali, H., Kern, M.A., Büttner-Herold, M., Jacobs, B., Völkl, S., Lischer, C., Kellner C., Berges J., Bitterer K., Saul D., Goel M., Link-Rachner C., Zernecke A., Weber D.A., Mougiakakos D., Mackensen A., Beilhack A., Bruns H. (2025). Augmented CD47 expression impairs alloreactive T-cell clearance after allo-HCT. Blood Journal, blood.2023023056. https://doi.org/10.1182/blood.2023023056.
  • Jaudas, F., Bartenschlager, F., Shashikadze, B., Santamaria, G., Reichart, D., Schnell, A., Stöckl, J.B., Degroote, R.L., Cambra, J.M., Graeber, S.Y., Bähr A., Kartmann H., Stefanska M., Liu H., Naumann-Bartsch N., Bruns H., Berges J., Hanselmann L., Stirm M., Krebs S., Deeg CA, Blum H, Schulz C, Zawada D, Janda M, Caballero-Posadas I, Kunzelmann K, Moretti A.., LaugwitzK.L., Kupatt C., Saalmüller A., Fröhlich T., Wolf E., Mall M.A., Mundhenk L., Gerner W., Klymiuk N. (2025). Perinatal dysfunction of innate immunity in cystic fibrosis. Sci Transl Med 17, eadk9145. https://doi.org/10.1126/scitranslmed.adk9145.
  • Weich A*, Berges J*, Flamann C, Bitterer K, Pal Singh K, Chambers D, Lischer C, Lai X, Wolkenhauer O, Berking C, Krönke G, Gupta S, Bruns H, Vera J (2025). Repurposed Clindamycin suppresses pyroptosis by inhibiting Caspase-1 in tumor-associated macrophages. Journal of Experimental & Clinical Cancer Research. 44:225 https://doi.org/10.1186/s13046-025-03478-5 (* shared first authorship)
  • Dürholz K, Ehnes L, Linnerbauer M, Schmid E, Danzer H, Schmidt M, Lößlein L, Amend L, Frech M, Azizov V, Schälter F, Gessner A, Lucas S, Lesker T, Taudte V, Hofmann J, Beyer F, Bootz-Maoz H, Reich Y, Romano H, Mauro D, Beckervordersandforth R, Kragsnaes M, Torkell E, Xiang W, Haghikia A, Akdis C, Ciccia F, Bäuerle T, Sarter K, Strowig T, Yissachar N, Schett G, Rothhammer V, Zaiss MM. Gut-specific H3R signaling orchestrates microglia-dependent resolution of peripheral inflammation. Clin. Invest. 2025 Jul 10;135(18):e184697. doi: 10.1172/JCI184697. eCollection 2025 Sep 16. PMID: 40638239
  • Adam J, Graf LM, Westermann S, Voehringer D, and Krappmann S (2025). Signaling events driving Aspergillus fumigatus-induced eosinophil activation. Int J Med Microbiol 318, 151641. 1016/j.ijmm.2024.151641.
  • Graf LM, Radtke D, and Voehringer D (2025). Regulation of eosinophil recruitment and heterogeneity during allergic airway inflammation. Front Allergy 6, 1585142. 10.3389/falgy.2025.1585142.
  • Amann M, Warstat R, Rechten KK, Theuer P, Schustereder M, Clavey S, Breit B, Einsle O, Hügle M, Petter M, Günther S. (2025). A Novel Inhibitor against the Bromodomain Protein 1 of the Malaria Pathogen Plasmodium Falciparum. ChemMedChem. 2025 Mar 18:e2500024. doi: 10.1002/cmdc.202500024. Epub ahead of print. PMID: 40099623.
  • Walter S, Schatz V, Petzold J, Schmidt C, Hoffmann S, Jantsch J, Gerlach RG. (2025). O2-dependent incapacitation of the Salmonella pathogenicity island 1 repressor HilE. Front Cell Infect Microbiol doi: 10.3389/fcimb.2025.1434254. eCollection 2025.
  • Meng X, Asadi-Asadabad S, Cao S, Song R, Lin Z, Safhi M, Qin Y, Tcheumi Tactoum E, Taudte V, Ekici A, Mielenz D, Wirtz S, Schett G, Bozec A. (2025). Metabolic rewiring controlled by HIF-1α tunes IgA-producing B-cell differentiation and intestinal inflammation. Cell Mol Immunol 22: 54-67. 10.1038/s41423-024-01233-y.
  • Martinek A, Deinzer A, Gerlach RG, Petzold J, Semmler L, Vorsatz C, Fallon PG, Schwartz C. (2025). Obesity impairs skin barrier function and facilitates allergic sensitization in mice. Allergy https://doi.org/10.1111/all.70067
  • Szperlinski M, Schermuly E, Lührmann A, Kozjak-Pavlovic V. (2025) Obligate intracellular bacteria and host cell death pathways – the matter of life and death. Cell and Tissue Research https://doi.org/10.1007/s00441-025-04014-9

 

 

2024

  • Biedermann A, Patra-Kneuer M, Mougiakakos D, Buttner-Herold M, Mangelberger-Eberl D, Berges J, Kellner C, Altmeyer S, Bittenbring JT, Augsberger C, Ilieva-Babinsky K, Haskamp S, Beier F, Lischer C, Vera J, Lührmann A, Bertz S, Volkl S, Jacobs B, Steidl S, Mackensen A, Bruns H. (2024). Blockade of the CD47/SIRPalpha checkpoint axis potentiates the macrophage-mediated antitumor efficacy of tafasitamab. Haematologica 109: 3928-40. 10.3324/haematol.2023.284795.
  • Lindner G, Walter A, Magnus CL, Rosenhammer K, Holoborodko B, Koch V, Hirsch S, Grossmann L, Li S, Knipe DM, DeLuca N, Schuler-Thurner B, Gross S, Schwertner B, Toelge M, Rohrhofer A, Stoeckl S, Bauer RJ, Knoll G, Ehrenschwender M, Haferkamp S, Schmidt B, Schuster P (2024). Comparison of the oncolytic activity of a replication-competent and a replication-deficient herpes simplex virus 1. Immunology 172, 279-294. doi: 10.1111/imm.13775. Epub 2024 Mar 5. PMID: 38444199
  • Herb M, Schatz V, Hadrian K, Hos D, Holoborodko B, Jantsch J, Brigo N (2024). Macrophage variants in laboratory research: most are well done, but some are RAW. Front Cell Infect Microbiol 14, 1457323. doi: 10.3389/fcimb.2024.1457323. eCollection 2024. PMID: 39445217
  • Bogdan C, Islam NA, Barinberg D, Soulat D, Schleicher U, Rai B (2024). The immunomicrotope of Leishmania control and persistence. Trends Parasitol 40(9), 788-804. doi: 10.1016/j.pt.2024.07.013. Epub 2024 Aug 21. PMID: 39174373
  • Schmidt K, Lerm D, Schmidt A, et al. Automated High-Throughput Live Cell Monitoring of Scratch Wound Closure. Biomedical Engineering and Computational Biology. 2024;15
  • Wrage M, Holland T, Nüse B, Kaltwasser J, Fröhlich J, Arnold H, Gießler C, Flamann C, Bruns H, Berges J, Daniel C, Hoffmann MH, Anish C, Seeberger PH, Bogdan C, Dettmer K, Rauh M, Mattner J (2024). Cell type-specific modulation of metabolic, immune-regulatory, and anti-microbial pathways by CD101. Mucosal Immunology 17, 892–910. https://doi.org/10.1016/j.mucimm.2024.06.004.
  • Lischer C, Eberhardt M, Flamann C, Berges J, Guse E, Wessely A, Weich A, Retzlaff J, Dorrie J, Schaft N, Wiesinger M, Marz J, Schuler-Thurner B, Knorr H, Gupta S, Singh KP, Schuler G, Heppt MV, Koch EAT, van Kleef ND, Freen-van Heeren JJ, Turksma AW, Wolkenhauer O, Hohberger B, Berking C, Bruns H, Vera J. (2024). Gene network-based and ensemble modeling-based selection of tumor-associated antigens with a predicted low risk of tissue damage for targeted immunotherapy. J Immunother Cancer1136/jitc-2023-008104.
  • Schälter F, Azizov V, Frech M, Durholz K, Schmid E, Hendel A, Sarfati I, Maeda Y, Sokolova M, Miyagawa I, Focke K, Sarter K, van Baarsen LGM, Krautwald S, Schett G, Zaiss MM (2024). CCL19-Positive Lymph Node Stromal Cells Govern the Onset of Inflammatory Arthritis via Tropomyosin Receptor Kinase. Arthritis Rheumatol 76: 857-68. doi:10.1002/art.42807

 

 

2023

  • Bayerl F, Bejarano DA, Bertacchi G, Doffin AC, Gobbini E, Hubert M, Li L, Meiser P, Pedde AM, Posch W, Rupp L, Schlitzer A, Schmitz M, Schraml BU, Uderhardt S, Valladeau-Guilemond J, Wilflingseder D, Zaderer V, Böttcher JP. Guidelines for visualization and analysis of DC in tissues using multiparameter fluorescence microscopy imaging methods. Eur J Immunol. 2023; doi: 10.1002/eji.202249923
  • Azizan S, Selvarajah SA, Tang J, Jeninga MD, Schulz D, Pareek K, Herr T, Day KP, de Koning-Ward TF, Petter M, Duffy MF (2023). The falciparum alternative histones Pf H2A.Z and Pf H2B.Z are dynamically acetylated and antagonized by PfSir2 histone deacetylases at heterochromatin boundaries. mBio 14(6):e0201423. doi: 10.1128/mbio.02014-23.
  • Frech M, Danzer H, Uchil P, Azizov V, Schmid E, Schalter F, Durholz K, Mauro D, Rauber S, Munoz L, Taher L, Ciccia F, Schober K, Irla M, Sarter K, Schett G, Zaiss MM (2023). Butyrophilin 2a2 (Btn2a2) expression on thymic epithelial cells promotes central T cell tolerance and prevents autoimmune disease. J Autoimmun 139: 103071. doi:10.1016/j.jaut.2023.103071
  • Bauer BU, Knittler MR, Andrack J, Berens C, Campe A, Christiansen B, Fasemore AM, Fischer SF, Ganter M, Körner S, Markert GR, Matthiesen S, Mertens-Scholz K, Rinkel S, Runge M, Schulze-Lührmann J, Ulbert S, Winter F, Frangoulidis D Lührmann A (2023). Interdisciplinary studies on Coxiella burnetii: From molecular to cellular, to host, to one health research. Int J Med Microbiol 313, 151590.
  • Lai C, Heinemann J, Schleicher U, Schett G, Bogdan C, Bozec A, Soulat D. Chronic Systemic Infection of Mice with Leishmania infantum Leads to Increased Bone Mass. J Bone Miner Res. 2023;38(1):86-102. doi: 10.1002/jbmr.4733. Epub 2022 Nov 16. Erratum in: J Bone Miner Res. 2023 Dec;38(12):1907. doi: 10.1002/jbmr.4935. PMID: 36332102.

 

 

2022

  • Sasse, C., Barinberg, D., Obermeyer, S., Debus, A., Schleicher, U., and Bogdan, C. (2022). Eosinophils, but Not Type 2 Innate Lymphoid Cells, Are the Predominant Source of Interleukin 4 during the Innate Phase of Leishmania major Pathogens 11. 10.3390/pathogens11080828.
  • Varela, F., Symowski, C., Pollock, J., Wirtz, S., & Voehringer, D. (2022). IL-4/IL-13-producing ILC2s are required for timely control of intestinal helminth infection in mice. European Journal of Immunology, 52(12), 1925–1933. https://doi.org/10.1002/eji.202249892
  • Quinn JE, Jeninga MD, Limm K, Pareek K, Meißgeier T, Bachmann A, Duffy MF, Petter M (2022). The putative bromodomain protein PfBDP7 of the human malaria parasite Plasmodium falciparum cooperates with PfBDP1 in the silencing of variant surface antigen expression. Front Cell Dev Biol 10:816558. doi: 10.3389/fcell.2022.816558.
  • Schaelter F, Frech M, Durholz K, Lucas S, Sarter K, Lebon L, Esser-von Bieren J, Dubey LK, Voehringer D, Schett G, Harris NL, Zaiss MM (2022). Acetate, a metabolic product of Heligmosomoides polygyrus, facilitates intestinal epithelial barrier breakdown in a FFAR2-dependent manner. Int J Parasitol 52: 591-601. doi:10.1016/j.ijpara.2022.04.004
  • Cordsmeier A, Rinkel S, Jeninga M, Schulze-Luehrmann J, Ölke M, Schmid B, Hasler D, Meister G, Häcker G, Petter M, Beare PA, Lührmann A (2022). The Coxiella burnetii T4SS effector protein AnkG hijacks the 7SK small nuclear ribonucleoprotein complex for reprogramming host cell transcription. PLoS Pathog 18, e1010266.
  • Dietschmann A, Schruefer S, Westermann S, Henkel F, Castiglione K, Willebrand R, Adam J, Ruland J, Lang R, Sheppard DC, Esser-von-Bieren J, Radtke D, Krappmann S, Voehringer D (2022). Phosphatidylinositol 3-kinase (PI3K) orchestrates Aspergillus fumigatus-induced eosinophil activation independently of canonical Toll-like receptor (TLR)/C-type-lectin receptor (CLR) signaling. mBio 13(4), e0123922. doi: 10.1128/mbio.01239-22. Epub 2022 Jun 13. PMID: 35695427