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DFG Research Training Group 2740 Immunomicrotope –

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  • Research
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      • Project area B „Metabolism“
      • Project area A “Micromilieu”
        • A1: Control of Citrobacter rodentium by oxygen-dependent B cell regulation
        • A2: Regulation of local tissue oxygenation in cutaneous leishmaniasis
        • A3: Induction and regulation of Coxiella burnetii persistence by microenvironmental factors
        • A4: The regulatory role of fibroblastic reticular cells during intestinal bacterial infections
        • A5: Impact of microenvironmental factors on neutrophil effector functions directed against Salmonella (S.) enterica serovar Typhimurium
        • A6: Eosinophils shape the tissue micro milieu and immune response in cutaneous leishmaniasis
        • A7: Characterization and mathematical modeling of the STAT6-regulated micro milieu in response to Nippostrongylus (N.) brasiliensis infections
        • B1: Molecular mechanisms linking metabolism and chromatin remodelling in the human malaria parasite Plasmodium falciparum
        • B2: Characterization and integrative bioinformatic modeling of metabolic and micromilieu factors promoting survival or control of Leishmania parasites
        • B3: Immuno-metabolomics of invasive aspergillosis
        • B4: Acetate, a secreted metabolic product of Heligmosomoides polygyrus facilitates tissue invasion and maintains chronic infection
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  4. Project area B “Metabolism”
  5. B1: Molecular mechanisms linking metabolism and chromatin remodelling in the human malaria parasite Plasmodium falciparum

B1: Molecular mechanisms linking metabolism and chromatin remodelling in the human malaria parasite Plasmodium falciparum

In page navigation: Research
  • Project areas
    • Project area A “Micromilieu”
      • A1: Control of Citrobacter rodentium by oxygen-dependent B cell regulation
      • A2: Regulation of local tissue oxygenation in cutaneous leishmaniasis
      • A3: Induction and regulation of Coxiella burnetii persistence by microenvironmental factors
      • A4: The regulatory role of fibroblastic reticular cells during intestinal bacterial infections
      • A5: Impact of microenvironmental factors on neutrophil effector functions directed against Salmonella (S.) enterica serovar Typhimurium
      • A6: Eosinophils shape the tissue micro milieu and immune response in cutaneous leishmaniasis
      • A7: Characterization and mathematical modeling of the STAT6-regulated micro milieu in response to Nippostrongylus (N.) brasiliensis infections
    • Project area B “Metabolism”
      • B1: Molecular mechanisms linking metabolism and chromatin remodelling in the human malaria parasite Plasmodium falciparum
      • B2: Characterization and integrative bioinformatic modeling of metabolic and micromilieu factors promoting survival or control of Leishmania parasites
      • B3: Immuno-metabolomics of invasive aspergillosis
      • B4: Acetate, a secreted metabolic product of Heligmosomoides polygyrus facilitates tissue invasion and maintains chronic infection
  • Publications

B1: Molecular mechanisms linking metabolism and chromatin remodelling in the human malaria parasite Plasmodium falciparum

B1: Molecular mechanisms linking metabolism and chromatin remodelling in the human malaria parasite Plasmodium falciparum

The protozoan parasite Plasmodium (P.) falciparum causes malaria by invading and manipulating human erythrocytes. For optimal transmission through its mosquito vector, the parasite needs to balance virulence and replication rate with the rate of differentiation into transmission stages. These decisions are governed by chromatin modifications and occur in response to environmental stimuli. However, it is unclear how the parasite senses environmental changes and how chromatin remodelling is achieved as a consequence. In this project we will test the hypothesis that microenvironment-induced metabolic reprogramming of P. falciparum parasites results in epigenetic changes that direct transcriptional differentiation programs. We will investigate how different conditions which P. falciparum encounters in the human host (hypoxia, acidosis, hemolysis, temperature, nutrient depletion) influence parasite acetyl-CoA metabolism and how this is reflected in the transcriptomic and epigenomic footprint by applying RNAseq and ChIPseq analyses. Further, we will use transgenic approaches to identify parasite proteins that are critical for chromatin remodelling processes in the malaria parasite.

Petter schema

 

Supervisor

Michaela Petter

Dr. rer. nat. Michaela Petter

Wasserturmstraße 3/5
91054 Erlangen
  • Phone number: +49 9131 85-22177
  • Email: michaela.petter@uk-erlangen.de
  • Website: https://www.mikrobiologie.uk-erlangen.de/en/research-teaching/research-groups/research-group-of-dr-m-petter/
More › Details for Michaela Petter
Universitätsklinikum Erlangen
Mikrobiologisches Institut

Wasserturmstr. 3/5
91054 Erlangen
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