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DFG Research Training Group 2740 Immunomicrotope –

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  • 1st International Symposium
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      • Project area B „Metabolism“
      • Project area A “Micromilieu”
        • A1: Control of Citrobacter rodentium by oxygen-dependent B cell regulation
        • A2: Regulation of local tissue oxygenation in cutaneous leishmaniasis
        • A3: Induction and regulation of Coxiella burnetii persistence by microenvironmental factors
        • A4: The regulatory role of fibroblastic reticular cells during intestinal bacterial infections
        • A5: Impact of microenvironmental factors on neutrophil effector functions directed against Salmonella (S.) enterica serovar Typhimurium
        • A6: Eosinophils shape the tissue micro milieu and immune response in cutaneous leishmaniasis
        • A7: Characterization and mathematical modeling of the STAT6-regulated micro milieu in response to Nippostrongylus (N.) brasiliensis infections
        • B1: Molecular mechanisms linking metabolism and chromatin remodelling in the human malaria parasite Plasmodium falciparum
        • B2: Characterization and integrative bioinformatic modeling of metabolic and micromilieu factors promoting survival or control of Leishmania parasites
        • B3: Immuno-metabolomics of invasive aspergillosis
        • B4: Acetate, a secreted metabolic product of Heligmosomoides polygyrus facilitates tissue invasion and maintains chronic infection
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  4. Project area B “Metabolism”
  5. B3: Immuno-metabolomics of invasive aspergillosis

B3: Immuno-metabolomics of invasive aspergillosis

In page navigation: Research
  • Project areas
    • Project area A “Micromilieu”
      • A1: Control of Citrobacter rodentium by oxygen-dependent B cell regulation
      • A2: Regulation of local tissue oxygenation in cutaneous leishmaniasis
      • A3: Induction and regulation of Coxiella burnetii persistence by microenvironmental factors
      • A4: The regulatory role of fibroblastic reticular cells during intestinal bacterial infections
      • A5: Impact of microenvironmental factors on neutrophil effector functions directed against Salmonella (S.) enterica serovar Typhimurium
      • A6: Eosinophils shape the tissue micro milieu and immune response in cutaneous leishmaniasis
      • A7: Characterization and mathematical modeling of the STAT6-regulated micro milieu in response to Nippostrongylus (N.) brasiliensis infections
    • Project area B “Metabolism”
      • B1: Molecular mechanisms linking metabolism and chromatin remodelling in the human malaria parasite Plasmodium falciparum
      • B2: Characterization and integrative bioinformatic modeling of metabolic and micromilieu factors promoting survival or control of Leishmania parasites
      • B3: Immuno-metabolomics of invasive aspergillosis
      • B4: Acetate, a secreted metabolic product of Heligmosomoides polygyrus facilitates tissue invasion and maintains chronic infection
  • Publications

B3: Immuno-metabolomics of invasive aspergillosis

B3: Immuno-metabolomics of invasive aspergillosis

Infections caused by the environmental saprobe Aspergillus fumigatus pose a significant threat to immunocompromised individuals. Conidia of this fungus serve as infectious propagules that are inhaled to reach the alveoli, where they are commonly eliminated via phagocytosis by resident and recruited cells of innate immunity. In an immunosuppressed host, however, germination and tissue invasion of fungal hyphae may occur to eventually result in hematogenous dissemination. Among the conditions that influence the pathogen-host encounter, the availability of nutrients as well as feeding by osmotrophy have to be regarded as strict prerequisites for pathogen proliferation but also for the cellular response of the host immune system. Future research in the RTG 2740 framework is focussed on the physiological interplay between fungal and host immune cells, based on the hypothesis that the nutritional status of either partner translates into aspects of pathogen recognition and elimination, therefore shaping the outcome of the pathogen/host encounter.

In essence, this tandem project aims at investigating to which extent infections with A. fumigatus result from fungal metabolites as well as from an altered metabolism and impaired antifungal activity of host myeloid cells.

 

Supervisor

Sven Krappmann

Prof. Dr. rer. nat. Sven Krappmann

Wasserturmstraße 3
91054 Erlangen
  • Phone number: +49 9131 85-32580
  • Email: sven.krappmann@uk-erlangen.de
  • Website: https://www.mikrobiologie.uk-erlangen.de/forschung-lehre/forschergruppen-arbeitsgruppen/ag-prof-s-krappmann/
More › Details for Sven Krappmann
Heiko Bruns

PD Dr. Heiko Bruns

Hartmannstr. 14
91052 Erlangen
  • Phone number: +49 9131 85-43163
  • Email: heiko.bruns@uk-erlangen.de
  • Website: http://www.medizin5.uk-erlangen.de/
More › Details for Heiko Bruns
Universitätsklinikum Erlangen
Mikrobiologisches Institut

Wasserturmstr. 3/5
91054 Erlangen
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