• Skip navigation
  • Skip to navigation
  • Skip to the bottom
Simulate organization breadcrumb open Simulate organization breadcrumb close
DFG Research Training Group 2740 Immunomicrotope –
  • FAUTo the central FAU website
  • Campo
  • UnivIS
  • Jobs
  • Map
  • Help

DFG Research Training Group 2740 Immunomicrotope –

Navigation Navigation close
  • Research
    • Project areas
      • Project area B „Metabolism“
      • Project area A “Micromilieu”
        • A1: Control of Citrobacter rodentium by oxygen-dependent B cell regulation
        • A2: Regulation of local tissue oxygenation in cutaneous leishmaniasis
        • A3: Induction and regulation of Coxiella burnetii persistence by microenvironmental factors
        • A4: The regulatory role of fibroblastic reticular cells during intestinal bacterial infections
        • A5: Impact of microenvironmental factors on neutrophil effector functions directed against Salmonella (S.) enterica serovar Typhimurium
        • A6: Eosinophils shape the tissue micro milieu and immune response in cutaneous leishmaniasis
        • A7: Characterization and mathematical modeling of the STAT6-regulated micro milieu in response to Nippostrongylus (N.) brasiliensis infections
        • B1: Molecular mechanisms linking metabolism and chromatin remodelling in the human malaria parasite Plasmodium falciparum
        • B2: Characterization and integrative bioinformatic modeling of metabolic and micromilieu factors promoting survival or control of Leishmania parasites
        • B3: Immuno-metabolomics of invasive aspergillosis
        • B4: Acetate, a secreted metabolic product of Heligmosomoides polygyrus facilitates tissue invasion and maintains chronic infection
        • Publications
    Portal Research
  • Program
    • Curriculum
      • RTG 2740-specific training measures
        • Lectures, seminars and research meetings
        • Workshops and practical courses
        • Annual and other scientific events
      • Training in general professional and transferable skills
      • Measures to promote national and international networking
    • Organization
    Portal Program
  • About us
    • Doctoral candidates
    • Supervisors
    • Coordinator
    Portal About us
  • How to apply
  1. Home
  2. Research
  3. Project areas
  4. Project area A “Micromilieu”
  5. A3: Induction and regulation of Coxiella burnetii persistence by microenvironmental factors

A3: Induction and regulation of Coxiella burnetii persistence by microenvironmental factors

In page navigation: Research
  • Project areas
    • Project area A “Micromilieu”
      • A1: Control of Citrobacter rodentium by oxygen-dependent B cell regulation
      • A2: Regulation of local tissue oxygenation in cutaneous leishmaniasis
      • A3: Induction and regulation of Coxiella burnetii persistence by microenvironmental factors
      • A4: The regulatory role of fibroblastic reticular cells during intestinal bacterial infections
      • A5: Impact of microenvironmental factors on neutrophil effector functions directed against Salmonella (S.) enterica serovar Typhimurium
      • A6: Eosinophils shape the tissue micro milieu and immune response in cutaneous leishmaniasis
      • A7: Characterization and mathematical modeling of the STAT6-regulated micro milieu in response to Nippostrongylus (N.) brasiliensis infections
    • Project area B “Metabolism”
      • B1: Molecular mechanisms linking metabolism and chromatin remodelling in the human malaria parasite Plasmodium falciparum
      • B2: Characterization and integrative bioinformatic modeling of metabolic and micromilieu factors promoting survival or control of Leishmania parasites
      • B3: Immuno-metabolomics of invasive aspergillosis
      • B4: Acetate, a secreted metabolic product of Heligmosomoides polygyrus facilitates tissue invasion and maintains chronic infection
  • Publications

A3: Induction and regulation of Coxiella burnetii persistence by microenvironmental factors

A3: Induction and regulation of Coxiella burnetii persistence by microenvironmental factors

Coxiella (C.) burnetii is the causative agent of the zoonotic disease Q fever, which can be either acute or chronic. While acute Q fever is a flu-like illness, chronic Q fever mainly manifest as a potentially life-treating endocarditis month or years after primary infection. The period prior outbreak of chronic Q fever is characterized by bacterial persistence, a physiologically dormant state that can cause relapsing infections and antibiotic resistance. Currently, it is unknown how C. burnetii persistence is induced or regulated.
We hypothesize that micromilieu factors are decisive for C. burnetii persistence and that different cell types provide diverse microenvironments. Accordingly, the project aims to characterize the induction of C. burnetii persistence under varying oxygen and tonicity conditions and to investigate the host cell metabolism, signaling and immune response of C. burnetii infected human macrophages and endothelial cell lines.

Lührmann Schmema

In macrophages C. burnetii are unable to replicate under hypoxic conditions. Hypoxia induces the stabilization of HIF1α, which in turn reduces the activation of STAT3. This leads to reduction of the TCA metabolite citrate, and a subsequent inhibition of C. burnetii replication (Hayek et al. 2019, Cell Reports). In contrast, C. burnetii replicates equally well in normoxic and hypoxic endothelial cells. The underlying reason is unclear.

Supervisor

Anja Lührmann

Prof. Dr. rer. nat. Anja Lührmann

Wasserturmstr. 3
91054 Erlangen
  • Phone number: +49 9131 85-22577
  • Email: anja.luehrmann@uk-erlangen.de
  • Website: http://www.mikrobiologie.uk-erlangen.de/
More › Details for Anja Lührmann

 

Universitätsklinikum Erlangen
Mikrobiologisches Institut

Wasserturmstr. 3/5
91054 Erlangen
  • Imprint
  • Privacy
  • Accessibility
Up