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DFG Research Training Group 2740 Immunomicrotope –

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  • Research
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      • Project area B „Metabolism“
      • Project area A “Micromilieu”
        • A1: Control of Citrobacter rodentium by oxygen-dependent B cell regulation
        • A2: Regulation of local tissue oxygenation in cutaneous leishmaniasis
        • A3: Induction and regulation of Coxiella burnetii persistence by microenvironmental factors
        • A4: The regulatory role of fibroblastic reticular cells during intestinal bacterial infections
        • A5: Impact of microenvironmental factors on neutrophil effector functions directed against Salmonella (S.) enterica serovar Typhimurium
        • A6: Eosinophils shape the tissue micro milieu and immune response in cutaneous leishmaniasis
        • A7: Characterization and mathematical modeling of the STAT6-regulated micro milieu in response to Nippostrongylus (N.) brasiliensis infections
        • B1: Molecular mechanisms linking metabolism and chromatin remodelling in the human malaria parasite Plasmodium falciparum
        • B2: Characterization and integrative bioinformatic modeling of metabolic and micromilieu factors promoting survival or control of Leishmania parasites
        • B3: Immuno-metabolomics of invasive aspergillosis
        • B4: Acetate, a secreted metabolic product of Heligmosomoides polygyrus facilitates tissue invasion and maintains chronic infection
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  5. A2: Regulation of local tissue oxygenation in cutaneous leishmaniasis

A2: Regulation of local tissue oxygenation in cutaneous leishmaniasis

In page navigation: Research
  • Project areas
    • Project area A “Micromilieu”
      • A1: Control of Citrobacter rodentium by oxygen-dependent B cell regulation
      • A2: Regulation of local tissue oxygenation in cutaneous leishmaniasis
      • A3: Induction and regulation of Coxiella burnetii persistence by microenvironmental factors
      • A4: The regulatory role of fibroblastic reticular cells during intestinal bacterial infections
      • A5: Impact of microenvironmental factors on neutrophil effector functions directed against Salmonella (S.) enterica serovar Typhimurium
      • A6: Eosinophils shape the tissue micro milieu and immune response in cutaneous leishmaniasis
      • A7: Characterization and mathematical modeling of the STAT6-regulated micro milieu in response to Nippostrongylus (N.) brasiliensis infections
    • Project area B “Metabolism”
      • B1: Molecular mechanisms linking metabolism and chromatin remodelling in the human malaria parasite Plasmodium falciparum
      • B2: Characterization and integrative bioinformatic modeling of metabolic and micromilieu factors promoting survival or control of Leishmania parasites
      • B3: Immuno-metabolomics of invasive aspergillosis
      • B4: Acetate, a secreted metabolic product of Heligmosomoides polygyrus facilitates tissue invasion and maintains chronic infection
  • Publications

A2: Regulation of local tissue oxygenation in cutaneous leishmaniasis

A2: Regulation of local tissue oxygenation in cutaneous leishmaniasis

Tissue oxygenation plays an important role in health and disease. Low oxygen (O2) levels prevail in infected tissues and thereby impair the O2-dependent antimicrobial effectors of professional phagocytes. This can promote the survival and replication of various pathogens including Leishmania (L.) major. Therefore, augmentation of local O2 levels in infected tissue might bear a therapeutic potential.
However, for that purpose a detailed knowledge of the regulatory mechanisms that drive low tissue O2 levels in infected tissues is required first. In this project, therefore, we would like to define the microenvironmental factors that are linked to low tissue oxygen levels in L. major lesions. In a next step, we aim to assess the contribution of these factors on lesional tissue oxygen and host defense.

Jantsch figure

Supervisors

Katja Dettmer Wilde

PD Dr. Katja Dettmer-Wilde

Am BioPark 9
93053 Regensburg
  • Phone number: +49-941-9435015
  • Email: katja.dettmer@ukr.de
  • Website: https://www.uni-regensburg.de/medicine/functional-genomics/staff/dr-katja-dettmer-wilde/index.html
More › Details for Katja Dettmer-Wilde
Jonathan Jantsch

Prof. Dr. Jonathan Jantsch

Franz-Josef-Strauß-Allee 11
93053 Regensburg
  • Phone number: +49-941-9446406
  • Email: jonathan.jantsch@ukr.de
  • Website: https://imhr.de/?page_id=959
More › Details for Jonathan Jantsch

 

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