A6: Eosinophils shape the tissue micro milieu and immune response in cutaneous leishmaniasis
A6: Eosinophils shape the tissue micromilieu and immune response in cutaneous leishmaniasis.
Eosinophils, which express antimicrobial molecules (e.g. eosinophilic cationic proteins, nitric oxide), cytokines (e.g. IL-4) and various types of immune receptors, are potent modulators of innate and adaptive immune responses. While eosinophils have been extensively studied in helminth infections, much less is known about their role in protozoan diseases such as cutaneous leishmaniasis (CL). Our preliminary results indicate that eosinophils might be critically involved in the immune defense of Leishmania. We therefore aim to analyse the influx, distribution and interaction partners of eosinophils in Leishmania-infected tissues and to clarify how eosinophils affect the micromilieu and the innate as well as adaptive immune response in different forms of CL.