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DFG Research Training Group 2740 Immunomicrotope –

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  • Research
    • Project areas
      • Project area B „Metabolism“
      • Project area A “Micromilieu”
        • A1: Control of Citrobacter rodentium by oxygen-dependent B cell regulation
        • A2: Regulation of local tissue oxygenation in cutaneous leishmaniasis
        • A3: Induction and regulation of Coxiella burnetii persistence by microenvironmental factors
        • A4: The regulatory role of fibroblastic reticular cells during intestinal bacterial infections
        • A5: Impact of microenvironmental factors on neutrophil effector functions directed against Salmonella (S.) enterica serovar Typhimurium
        • A6: Eosinophils shape the tissue micro milieu and immune response in cutaneous leishmaniasis
        • A7: Characterization and mathematical modeling of the STAT6-regulated micro milieu in response to Nippostrongylus (N.) brasiliensis infections
        • B1: Molecular mechanisms linking metabolism and chromatin remodelling in the human malaria parasite Plasmodium falciparum
        • B2: Characterization and integrative bioinformatic modeling of metabolic and micromilieu factors promoting survival or control of Leishmania parasites
        • B3: Immuno-metabolomics of invasive aspergillosis
        • B4: Acetate, a secreted metabolic product of Heligmosomoides polygyrus facilitates tissue invasion and maintains chronic infection
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  5. A6: Eosinophils shape the tissue micro milieu and immune response in cutaneous leishmaniasis

A6: Eosinophils shape the tissue micro milieu and immune response in cutaneous leishmaniasis

In page navigation: Research
  • Project areas
    • Project area A “Micromilieu”
      • A1: Control of Citrobacter rodentium by oxygen-dependent B cell regulation
      • A2: Regulation of local tissue oxygenation in cutaneous leishmaniasis
      • A3: Induction and regulation of Coxiella burnetii persistence by microenvironmental factors
      • A4: The regulatory role of fibroblastic reticular cells during intestinal bacterial infections
      • A5: Impact of microenvironmental factors on neutrophil effector functions directed against Salmonella (S.) enterica serovar Typhimurium
      • A6: Eosinophils shape the tissue micro milieu and immune response in cutaneous leishmaniasis
      • A7: Characterization and mathematical modeling of the STAT6-regulated micro milieu in response to Nippostrongylus (N.) brasiliensis infections
    • Project area B “Metabolism”
      • B1: Molecular mechanisms linking metabolism and chromatin remodelling in the human malaria parasite Plasmodium falciparum
      • B2: Characterization and integrative bioinformatic modeling of metabolic and micromilieu factors promoting survival or control of Leishmania parasites
      • B3: Immuno-metabolomics of invasive aspergillosis
      • B4: Acetate, a secreted metabolic product of Heligmosomoides polygyrus facilitates tissue invasion and maintains chronic infection
  • Publications

A6: Eosinophils shape the tissue micro milieu and immune response in cutaneous leishmaniasis

A6: Eosinophils shape the tissue micromilieu and immune response in cutaneous leishmaniasis.

Eosinophils, which express antimicrobial molecules (e.g. eosinophilic cationic proteins, nitric oxide), cytokines (e.g. IL-4) and various types of immune receptors, are potent modulators of innate and adaptive immune responses. While eosinophils have been extensively studied in helminth infections, much less is known about their role in protozoan diseases such as cutaneous leishmaniasis (CL). Our preliminary results indicate that eosinophils might be critically involved in the immune defense of Leishmania. We therefore aim to analyse the influx, distribution and interaction partners of eosinophils in Leishmania-infected tissues and to clarify how eosinophils affect the micromilieu and the innate as well as adaptive immune response in different forms of CL.

 

Schleicher Grafik

Supervisor

Ulrike Schleicher

PD Dr. rer. nat Ulrike Schleicher

Wasserturmstr. 3/5
91054 Erlangen
  • Phone number: +49 9131 85-23647
  • Email: ulrike.schleicher@uk-erlangen.de
  • Website: https://www.mikrobiologie.uk-erlangen.de/forschung-lehre/forschergruppen-arbeitsgruppen/ag-pd-dr-u-schleicher/
More › Details for Ulrike Schleicher
Universitätsklinikum Erlangen
Mikrobiologisches Institut

Wasserturmstr. 3/5
91054 Erlangen
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