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DFG Research Training Group 2740 Immunomicrotope –

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  • Research
    • Project areas
      • Project area B „Metabolism“
      • Project area A “Micromilieu”
        • A1: Control of Citrobacter rodentium by oxygen-dependent B cell regulation
        • A2: Regulation of local tissue oxygenation in cutaneous leishmaniasis
        • A3: Induction and regulation of Coxiella burnetii persistence by microenvironmental factors
        • A4: The regulatory role of fibroblastic reticular cells during intestinal bacterial infections
        • A5: Impact of microenvironmental factors on neutrophil effector functions directed against Salmonella (S.) enterica serovar Typhimurium
        • A6: Eosinophils shape the tissue micro milieu and immune response in cutaneous leishmaniasis
        • A7: Characterization and mathematical modeling of the STAT6-regulated micro milieu in response to Nippostrongylus (N.) brasiliensis infections
        • B1: Molecular mechanisms linking metabolism and chromatin remodelling in the human malaria parasite Plasmodium falciparum
        • B2: Characterization and integrative bioinformatic modeling of metabolic and micromilieu factors promoting survival or control of Leishmania parasites
        • B3: Immuno-metabolomics of invasive aspergillosis
        • B4: Acetate, a secreted metabolic product of Heligmosomoides polygyrus facilitates tissue invasion and maintains chronic infection
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  4. Project area A “Micromilieu”
  5. A4: The regulatory role of fibroblastic reticular cells during intestinal bacterial infections

A4: The regulatory role of fibroblastic reticular cells during intestinal bacterial infections

In page navigation: Research
  • Project areas
    • Project area A “Micromilieu”
      • A1: Control of Citrobacter rodentium by oxygen-dependent B cell regulation
      • A2: Regulation of local tissue oxygenation in cutaneous leishmaniasis
      • A3: Induction and regulation of Coxiella burnetii persistence by microenvironmental factors
      • A4: The regulatory role of fibroblastic reticular cells during intestinal bacterial infections
      • A5: Impact of microenvironmental factors on neutrophil effector functions directed against Salmonella (S.) enterica serovar Typhimurium
      • A6: Eosinophils shape the tissue micro milieu and immune response in cutaneous leishmaniasis
      • A7: Characterization and mathematical modeling of the STAT6-regulated micro milieu in response to Nippostrongylus (N.) brasiliensis infections
    • Project area B “Metabolism”
      • B1: Molecular mechanisms linking metabolism and chromatin remodelling in the human malaria parasite Plasmodium falciparum
      • B2: Characterization and integrative bioinformatic modeling of metabolic and micromilieu factors promoting survival or control of Leishmania parasites
      • B3: Immuno-metabolomics of invasive aspergillosis
      • B4: Acetate, a secreted metabolic product of Heligmosomoides polygyrus facilitates tissue invasion and maintains chronic infection
  • Publications

A4: The regulatory role of fibroblastic reticular cells during intestinal bacterial infections

A4: The regulatory role of fibroblastic reticular cells during intestinal bacterial infections

Gastrointestinal infections with bacterial pathogens are responsible for substantial morbidity and mortality worldwide. Fibroblastic reticular cells (FRCs) are stromal cells that orchestrate the microarchitecture and the immune cell composition within lymphoid organs and thus potentially play vital roles during infections. We found in preliminary experiments alterations in the intestinal FRC compartment during gut infection and identified host factors such as interferons ­that may contribute to these processes. In this project, we aim to further characterize signalling pathways in FRC controlling the structural dynamics and functional changes within lymphoid organs during infections with bacterial pathogens. Established infection models will be employed by advanced imaging techniques such as intravital- and light sheet microscopy. We will furthermore use in vitro experiments to characterize stromal cell responses by next generation sequencing and models systems with conditional inactivation of inflammation-associated transcription factors to define critical factors required for a stromal microenvironment providing effective pathogen clearance.

Schema Wirtz

Supervisor

Stefan Wirtz

PD Dr. rer. nat. Dr. med. habil. Stefan Wirtz

Hartmannstraße 14
91052 Erlangen
  • Phone number: 09131853588235960
  • Mobile phone: +49 9131 85-45075
  • Email: stefan.wirtz@uk-erlangen.de
  • Website: http://www.medizin1.uk-erlangen.de/
More › Details for Stefan Wirtz
Universitätsklinikum Erlangen
Mikrobiologisches Institut

Wasserturmstr. 3/5
91054 Erlangen
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