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DFG Research Training Group 2740 Immunomicrotope –

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  • Research
    • Project areas
      • Project area B „Metabolism“
      • Project area A “Micromilieu”
        • A1: Control of Citrobacter rodentium by oxygen-dependent B cell regulation
        • A2: Regulation of local tissue oxygenation in cutaneous leishmaniasis
        • A3: Induction and regulation of Coxiella burnetii persistence by microenvironmental factors
        • A4: The regulatory role of fibroblastic reticular cells during intestinal bacterial infections
        • A5: Impact of microenvironmental factors on neutrophil effector functions directed against Salmonella (S.) enterica serovar Typhimurium
        • A6: Eosinophils shape the tissue micro milieu and immune response in cutaneous leishmaniasis
        • A7: Characterization and mathematical modeling of the STAT6-regulated micro milieu in response to Nippostrongylus (N.) brasiliensis infections
        • B1: Molecular mechanisms linking metabolism and chromatin remodelling in the human malaria parasite Plasmodium falciparum
        • B2: Characterization and integrative bioinformatic modeling of metabolic and micromilieu factors promoting survival or control of Leishmania parasites
        • B3: Immuno-metabolomics of invasive aspergillosis
        • B4: Acetate, a secreted metabolic product of Heligmosomoides polygyrus facilitates tissue invasion and maintains chronic infection
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  5. A1: Control of Citrobacter rodentium by oxygen-dependent B cell regulation

A1: Control of Citrobacter rodentium by oxygen-dependent B cell regulation

In page navigation: Research
  • Project areas
    • Project area A “Micromilieu”
      • A1: Control of Citrobacter rodentium by oxygen-dependent B cell regulation
      • A2: Regulation of local tissue oxygenation in cutaneous leishmaniasis
      • A3: Induction and regulation of Coxiella burnetii persistence by microenvironmental factors
      • A4: The regulatory role of fibroblastic reticular cells during intestinal bacterial infections
      • A5: Impact of microenvironmental factors on neutrophil effector functions directed against Salmonella (S.) enterica serovar Typhimurium
      • A6: Eosinophils shape the tissue micro milieu and immune response in cutaneous leishmaniasis
      • A7: Characterization and mathematical modeling of the STAT6-regulated micro milieu in response to Nippostrongylus (N.) brasiliensis infections
    • Project area B “Metabolism”
      • B1: Molecular mechanisms linking metabolism and chromatin remodelling in the human malaria parasite Plasmodium falciparum
      • B2: Characterization and integrative bioinformatic modeling of metabolic and micromilieu factors promoting survival or control of Leishmania parasites
      • B3: Immuno-metabolomics of invasive aspergillosis
      • B4: Acetate, a secreted metabolic product of Heligmosomoides polygyrus facilitates tissue invasion and maintains chronic infection
  • Publications

A1: Control of Citrobacter rodentium by oxygen-dependent B cell regulation

A1: Control of Citrobacter rodentium by oxygen-dependent B cell regulation

Citrobacter rodentium is a murine model pathogen for human enteropathogenic Escherichia coli, which colonizes the lumen and mucosal surface of the colon. It was previously shown that defenses against C. rodentium depends on B cells, IgA antibodies and Th17 activation. Recently, we have shown that HIF-1α induces regulatory B cell expansion and IL-10 production. It is likely that IL-10 produced by regulatory B cells protects against gut epithelial cell damage by suppression of Th1 and Th17 cell functions. Our preliminary data suggest that IgA positive plasma cells are also dependent of HIF-1α expression. In this project, we will characterize antibody production in the intestine of HIF-1α deficient in B cells in the context of dysbioses. Furthermore, we will determine the impact of HIF-1α deficiency in B cells during C. rodentium oral infection. RNA sequencing methodology and multi-color flow cytometry will be used to characterize IgA plasma cell in steady state and during C. rodentium infection.

Supervisor

Aline Bozec

Prof. Dr. rer. nat. Aline Bozec

Glückstr. 6
91054 Erlangen
  • Phone number: +49 9131 85-29314
  • Email: bozec.aline@outlook.com
  • Website: https://www.medizin3.uk-erlangen.de/forschung/arbeitsgruppen/ag-prof-dr-a-bozec/
More › Details for Aline Bozec
Universitätsklinikum Erlangen
Mikrobiologisches Institut

Wasserturmstr. 3/5
91054 Erlangen
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