• Skip navigation
  • Skip to navigation
  • Skip to the bottom
Simulate organization breadcrumb open Simulate organization breadcrumb close
DFG Research Training Group 2740 Immunomicrotope –
  • FAUTo the central FAU website
  • Campo
  • UnivIS
  • Jobs
  • Map
  • Help

DFG Research Training Group 2740 Immunomicrotope –

Navigation Navigation close
  • Research
    • Project areas
      • Project area B „Metabolism“
      • Project area A “Micromilieu”
        • A1: Control of Citrobacter rodentium by oxygen-dependent B cell regulation
        • A2: Regulation of local tissue oxygenation in cutaneous leishmaniasis
        • A3: Induction and regulation of Coxiella burnetii persistence by microenvironmental factors
        • A4: The regulatory role of fibroblastic reticular cells during intestinal bacterial infections
        • A5: Impact of microenvironmental factors on neutrophil effector functions directed against Salmonella (S.) enterica serovar Typhimurium
        • A6: Eosinophils shape the tissue micro milieu and immune response in cutaneous leishmaniasis
        • A7: Characterization and mathematical modeling of the STAT6-regulated micro milieu in response to Nippostrongylus (N.) brasiliensis infections
        • B1: Molecular mechanisms linking metabolism and chromatin remodelling in the human malaria parasite Plasmodium falciparum
        • B2: Characterization and integrative bioinformatic modeling of metabolic and micromilieu factors promoting survival or control of Leishmania parasites
        • B3: Immuno-metabolomics of invasive aspergillosis
        • B4: Acetate, a secreted metabolic product of Heligmosomoides polygyrus facilitates tissue invasion and maintains chronic infection
        • Publications
    Portal Research
  • Program
    • Curriculum
      • RTG 2740-specific training measures
        • Lectures, seminars and research meetings
        • Workshops and practical courses
        • Annual and other scientific events
      • Training in general professional and transferable skills
      • Measures to promote national and international networking
    • Organization
    Portal Program
  • About us
    • Doctoral candidates
    • Supervisors
    • Coordinator
    Portal About us
  • How to apply
  1. Home
  2. Research
  3. Project areas
  4. Project area A “Micromilieu”
  5. A5: Impact of microenvironmental factors on neutrophil effector functions directed against Salmonella (S.) enterica serovar Typhimurium

A5: Impact of microenvironmental factors on neutrophil effector functions directed against Salmonella (S.) enterica serovar Typhimurium

In page navigation: Research
  • Project areas
    • Project area A “Micromilieu”
      • A1: Control of Citrobacter rodentium by oxygen-dependent B cell regulation
      • A2: Regulation of local tissue oxygenation in cutaneous leishmaniasis
      • A3: Induction and regulation of Coxiella burnetii persistence by microenvironmental factors
      • A4: The regulatory role of fibroblastic reticular cells during intestinal bacterial infections
      • A5: Impact of microenvironmental factors on neutrophil effector functions directed against Salmonella (S.) enterica serovar Typhimurium
      • A6: Eosinophils shape the tissue micro milieu and immune response in cutaneous leishmaniasis
      • A7: Characterization and mathematical modeling of the STAT6-regulated micro milieu in response to Nippostrongylus (N.) brasiliensis infections
    • Project area B “Metabolism”
      • B1: Molecular mechanisms linking metabolism and chromatin remodelling in the human malaria parasite Plasmodium falciparum
      • B2: Characterization and integrative bioinformatic modeling of metabolic and micromilieu factors promoting survival or control of Leishmania parasites
      • B3: Immuno-metabolomics of invasive aspergillosis
      • B4: Acetate, a secreted metabolic product of Heligmosomoides polygyrus facilitates tissue invasion and maintains chronic infection
  • Publications

A5: Impact of microenvironmental factors on neutrophil effector functions directed against Salmonella (S.) enterica serovar Typhimurium

A5: Impact of microenvironmental factors on neutrophil effector functions directed against Salmonella (S.) enterica serovar Typhimurium

Neutrophils are at the frontline of pathogen defense and equipped with a highly potent antimicrobial arsenal. Upon infection, extravasated neutrophils often face extreme conditions and have to function in complex and unpredictable environments. How neutrophils acutely integrate tissular signals to adapt their immune effector functions accordingly, has not yet been addressed. We have recently established a novel imaging platform that allows for the dynamic visualization of the dynamic behavior of extravascular immune effector cells with high spatial and temporal resolution, yet within the physiological context of an intact tissue (in situ peritoneal imaging). This experimental setup allows for the detailed analysis of acute neutrophil anti-pathogen activities under a variety of microenvironmental conditions. We will study neutrophilic anti-pathogen response, using an ex vivo tissue-bioimaging platform (explanted peritoneal serosa with pre-elicited, neutrophils). Here, static and dynamic high-resolution microscopy (confocal, 2-photon) will be combined with in situ metabolic monitoring and further RNAseq, metabolomic and proteomic approaches. Our approach will enable us to modify parameters of the tissue milieu (e.g., pH, oxygen saturation, ion content, tonicity) and thus directly study the impact of microenvironmental factors on effector functions of neutrophils in a living tissue.

Project A5_Uderhardt

Supervisor

Stefan Uderhardt

Prof. Dr. med. Stefan Uderhardt

Universitätsstr. 25a
91054 Erlangen
  • Phone number: +49 9131 85-70350
  • Email: stefan.uderhardt@uk-erlangen.de
  • Website: https://www.medizin3.uk-erlangen.de/forschung/arbeitsgruppen/ag-prof-dr-s-uderhardt/
More › Details for Stefan Uderhardt
Universitätsklinikum Erlangen
Mikrobiologisches Institut

Wasserturmstr. 3/5
91054 Erlangen
  • Imprint
  • Privacy
  • Accessibility
Up