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DFG Research Training Group 2740 Immunomicrotope –

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  • Research
    • Project areas
      • Project area B „Metabolism“
      • Project area A “Micromilieu”
        • A1: Control of Citrobacter rodentium by oxygen-dependent B cell regulation
        • A2: Regulation of local tissue oxygenation in cutaneous leishmaniasis
        • A3: Induction and regulation of Coxiella burnetii persistence by microenvironmental factors
        • A4: The regulatory role of fibroblastic reticular cells during intestinal bacterial infections
        • A5: Impact of microenvironmental factors on neutrophil effector functions directed against Salmonella (S.) enterica serovar Typhimurium
        • A6: Eosinophils shape the tissue micro milieu and immune response in cutaneous leishmaniasis
        • A7: Characterization and mathematical modeling of the STAT6-regulated micro milieu in response to Nippostrongylus (N.) brasiliensis infections
        • B1: Molecular mechanisms linking metabolism and chromatin remodelling in the human malaria parasite Plasmodium falciparum
        • B2: Characterization and integrative bioinformatic modeling of metabolic and micromilieu factors promoting survival or control of Leishmania parasites
        • B3: Immuno-metabolomics of invasive aspergillosis
        • B4: Acetate, a secreted metabolic product of Heligmosomoides polygyrus facilitates tissue invasion and maintains chronic infection
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  4. Project area A “Micromilieu”
  5. A7: Characterization and mathematical modeling of the STAT6-regulated micro milieu in response to Nippostrongylus (N.) brasiliensis infections

A7: Characterization and mathematical modeling of the STAT6-regulated micro milieu in response to Nippostrongylus (N.) brasiliensis infections

In page navigation: Research
  • Project areas
    • Project area A “Micromilieu”
      • A1: Control of Citrobacter rodentium by oxygen-dependent B cell regulation
      • A2: Regulation of local tissue oxygenation in cutaneous leishmaniasis
      • A3: Induction and regulation of Coxiella burnetii persistence by microenvironmental factors
      • A4: The regulatory role of fibroblastic reticular cells during intestinal bacterial infections
      • A5: Impact of microenvironmental factors on neutrophil effector functions directed against Salmonella (S.) enterica serovar Typhimurium
      • A6: Eosinophils shape the tissue micro milieu and immune response in cutaneous leishmaniasis
      • A7: Characterization and mathematical modeling of the STAT6-regulated micro milieu in response to Nippostrongylus (N.) brasiliensis infections
    • Project area B “Metabolism”
      • B1: Molecular mechanisms linking metabolism and chromatin remodelling in the human malaria parasite Plasmodium falciparum
      • B2: Characterization and integrative bioinformatic modeling of metabolic and micromilieu factors promoting survival or control of Leishmania parasites
      • B3: Immuno-metabolomics of invasive aspergillosis
      • B4: Acetate, a secreted metabolic product of Heligmosomoides polygyrus facilitates tissue invasion and maintains chronic infection
  • Publications

A7: Characterization and mathematical modeling of the STAT6-regulated micro milieu in response to Nippostrongylus (N.) brasiliensis infections

A7: Characterization and mathematical modeling of the STAT6-regulated
micromilieu in response to Nippostrongylus (.) brasiliensis infections

Helminth infections affect about 1/3 of the world population and to date there are no helminth-specific vaccines available. IL-4/IL-13-induced activation of the transcription factor STAT6 in non-hematopoetic cells plays a critical role for worm expulsion during infection with gastrointestinal helminths. We will investigate how expression of STAT6-regulated genes in different cell types cause changes of the immunomicrotope (mucus production, pH, tissue tonicity, short chained fatty acids) in skin, lung and intestine. We will further determine how the worm transcriptome changes during colonization of the small intestine in wild-type versus STAT6-deficient mice. In close collaboration with Vasily Zaburdaev (part B of this project) we will use mathematical modeling to address changes of individual parameters on tissue migration and expulsion of N. brasiliensis.

 

A8_overview

Supervisors

David Vöhringer

Prof. Dr. rer. nat. David Vöhringer

Wasserturmstraße 3/5
91054 Erlangen
  • Phone number: +49 9131 85-32735
  • Email: david.voehringer@uk-erlangen.de
  • Website: https://www.infektionsbiologie.uk-erlangen.de/
More › Details for David Vöhringer
Vasily Zaburdaev

Prof. Dr. Vasily Zaburdaev

Cauerstr. 11
91058 Erlangen
  • Phone number: +49 9131 85-67123
  • Email: vasily.zaburdaev@fau.de
  • Website: https://www.mathlife.nat.fau.de/
More › Details for Vasily Zaburdaev
Universitätsklinikum Erlangen
Mikrobiologisches Institut

Wasserturmstr. 3/5
91054 Erlangen
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