Publications by principal investigators

List of published research by PIs (relevant to the research program)

 

Prof. Dr. med. Christian Bogdan

  1. Esse J, Träger J, Steininger P, Bihlmaier K, Fürst J, Bardonicsek-Depnering Z, Naumann-Bartsch N, Morhart P, Castellanos I, Krause SW, Herbst L, Strauß R, Chada M, Korn K, Valenza G, Teschner D, Bogdan C, Held J. (2025). Metagenomic analysis of microbial cell-free DNA from plasma of patients with suspected infections: performance and therapeutic impact in clinical routine. Clin Microbiol Infect. 31(6): 1018-1025 1016/j.cmi.2025.02.016.
  2. Debus D, Genc S, Kurz P, Holzer M, Bauer K, Heimke-Brinck R, Baier M, Sebald H, Debus A, Bogdan C*, Stahl KW*. (2022). Local Treatment of a Leishmania tropica Infection with a Novel Filmogenic Preparation of Pharmaceutical Sodium Chlorite (LeiProtect®). Am J Trop Med Hyg 106: 857-60. 10.4269/ajtmh.21-0962. (*shared senior & corresponding authorship)
  3. Baier J, Gansbauer M, Giessler C, Arnold H, Muske M, Schleicher U, Lukassen S, Ekici AB, Rauh M, Daniel C, Hartmann A, Schmid B, Tripal P, Dettmer K, Oefner PJ, Atreya R, Wirtz S, Bogdan C, Mattner J. (2020). Arginase expression impedes the resolution of intestinal inflammation by altering the fecal microbiome and the metabolome. J Clin Invest 130: 5703-20. 10.1172/JCI126923.
  4. Schleicher U, Paduch K, Debus A, Obermeyer S, König T, Kling JC, Ribechini E, Dudziak D, Mougiakakos D, Murray PJ, Ostuni R, Korner H, Bogdan C. (2016). TNF-Mediated Restriction of Arginase 1 Expression in Myeloid Cells Triggers Type 2 NO Synthase Activity at the Site of Infection. Cell Rep 15: 1062-75. 10.1016/j.celrep.2016.04.001
  5. Nairz M, Schleicher U, Schroll A, Sonnweber T, Theurl I, Ludwiczek S, Talasz H, Brandacher G, Moser PL, Muckenthaler MU, Fang FC, Bogdan C, Weiss G. (2013). Nitric oxide-mediated regulation of ferroportin-1 controls macrophage iron homeostasis and immune function in Salmonella infection. J Exp Med 210: 855-73. 10.1084/jem.20121946.
  6. Schleicher U, Liese J, Knippertz I, Kurzmann C, Hesse A, Heit A, Fischer JA, Weiss S, Kalinke U, Kunz S, Bogdan C. (2007). NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCs. J Exp Med 204: 893-906. 10.1084/jem.20061293.
  7. Bogdan C, Donhauser N, Döring R, Rollinghoff M, Diefenbach A, Rittig MG. (2000). Fibroblasts as host cells in latent leishmaniosis. J Exp Med 191: 2121-30. 10.1084/jem.191.12.2121.
  8. Diefenbach A, Schindler H, Röllinghoff M, Yokoyama W, Bogdan C. (1999). Requirement for type 2 NO-synthase for IL-12 signaling in innate immunity. Science 284: 951-5. doi: 10.1126/science.284.5416.951.
  9. Stenger S, Donhauser N, Thuring H, Röllinghoff M and Bogdan C. (1996). Reactivation of latent leishmaniasis by inhibition of inducible NO synthase. J Exp Med 183: 1501-14.
  10. Bogdan C, Vodovotz Y and Nathan C. (1991). Macrophage deactivation by interleukin 10. J Exp Med 174: 1549-55. doi: 10.1084/jem.174.6.1549.

 

Prof. Aline Bozec, PhD

  1. Meng X, Asadi-Asadabad S, Cao S, Song R, Lin Z, Safhi M, Qin Y, Tcheumi Tactoum E, Taudte V, Ekici A, Mielenz D, Wirtz S, Schett G, Bozec A. (2025). Metabolic rewiring controlled by HIF-1α tunes IgA-producing B-cell differentiation and intestinal inflammation. Cell Mol Immunol 22: 54-67. 10.1038/s41423-024-01233-y.
  2. Jia Y, Li R, Li Y, Kachler K, Meng X, Gießl A, Qin Y, Zhang F, Liu N, Andreev D, Schett G, Bozec A. (2025). Melanoma bone metastasis-induced osteocyte ferroptosis via the HIF1α-HMOX1 axis. Bone Res 13: 9. 10.1038/s41413-024-00384-y.
  3. Andreev D, Kachler K, Liu M, Chen Z, Krishnacoumar B, Ringer M, Frey S, Krönke G, Voehringer D, Schett G, Bozec A. (2024). Eosinophils preserve bone homeostasis by inhibiting excessive osteoclast formation and activity via eosinophil peroxidase. Nat Commun 15: 1067. 10.1038/s41467-024-45261-8.
  4. Cao S, Li Y, Song R, Meng X, Fuchs M, Liang C, Kachler K, Meng X, Wen J, Schlötzer-Schrehardt U, Taudte V, Gessner A, Kunz M, Schleicher U, Zaiss MM, Kastbom A, Chen X, Schett G, Bozec A. (2024). L-arginine metabolism inhibits arthritis and inflammatory bone loss. Ann Rheum Dis 83: 72-87. 10.1136/ard-2022-223626.
  5. Kachler K, Andreev D, Thapa S, Royzman D, Gießl A, Karuppusamy S, Llerins Perez M, Liu M, Hofmann J, Gessner A, Meng X, Rauber S, Steinkasserer A, Fromm M, Schett G, Bozec A. (2024). Acod1-mediated inhibition of aerobic glycolysis suppresses osteoclast differentiation and attenuates bone erosion in arthritis. Ann Rheum Dis 83: 1691-706. 10.1136/ard-2023-224774.
  6. Lyu P, Wen J, Zhang W, Liu N, Stolzer I, Gießl A, Jia Y, Mauro D, Zhang F, Ciccia F, Soulat D, Günther C, Schett G, Bozec A. (2024). Expression of HIF1α in intestinal epithelium restricts arthritis inflammation by inhibiting RIPK3-induced cell death machinery. Ann Rheum Dis 83: 984-97. 10.1136/ard-2023-224491.
  7. Sonomoto K, Song R, Eriksson D, Hahn AM, Meng X, Lyu P, Cao S, Liu N, Taudte RV, Wirtz S, Tanaka Y, Winkler TH, Schett G, Soulat D, Bozec A. (2023). High-fat-diet-associated intestinal microbiota exacerbates psoriasis-like inflammation by enhancing systemic γδ T cell IL-17 production. Cell Rep 42: 112713. 10.1016/j.celrep.2023.112713.
  8. Wen J, Lyu P, Stolzer I, Xu J, Gießl A, Lin Z, Andreev D, Kachler K, Song R, Meng X, Cao S, Guggino G, Ciccia F, Günther C, Schett G, Bozec A. (2022). Epithelial HIF2α expression induces intestinal barrier dysfunction and exacerbation of arthritis. Ann Rheum Dis 81: 1119-30. 10.1136/annrheumdis-2021-222035.
  9. Andreev D, Liu M, Weidner D, Kachler K, Faas M, Grüneboom A, Schlötzer-Schrehardt U, Muñoz LE, Steffen U, Grötsch B, Killy B, Krönke G, Luebke AM, Niemeier A, Wehrhan F, Lang R, Schett G, Bozec A. (2020). Osteocyte necrosis triggers osteoclast-mediated bone loss through macrophage-inducible C-type lectin. J Clin Invest 130: 4811-30. 10.1172/jci134214.
  10. Meng X, Grötsch B, Luo Y, Knaup KX, Wiesener MS, Chen XX, Jantsch J, Fillatreau S, Schett G, Bozec A. (2018). HIF-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease. Nat Commun 9: 251. 10.1038/s41467-017-02683-x.

 

PD Dr. rer.nat. Heiko Bruns

  1. Flamann CS, Shaikh H, Matos C, Kreutz M, Ali H, Kern MA, Buttner-Herold M, Jacobs B, Volkl S, Lischer C, Kellner C, Berges J, Bitterer K, Saul D, Goel M, Link-Rachner C, Zernecke A, Weber DA, Mougiakakos D, Mackensen A, Beilhack A, Bruns H. (2025). Augmented CD47 expression impairs alloreactive T-cell clearance after allo-HCT. Blood 10.1182/blood.2023023056.
  2. Biedermann A, Patra-Kneuer M, Mougiakakos D, Buttner-Herold M, Mangelberger-Eberl D, Berges J, Kellner C, Altmeyer S, Bittenbring JT, Augsberger C, Ilieva-Babinsky K, Haskamp S, Beier F, Lischer C, Vera J, Lührmann A, Bertz S, Volkl S, Jacobs B, Steidl S, Mackensen A, Bruns H. (2024). Blockade of the CD47/SIRPalpha checkpoint axis potentiates the macrophage-mediated antitumor efficacy of tafasitamab. Haematologica 109: 3928-40. 10.3324/haematol.2023.284795.
  3. Lischer C, Eberhardt M, Flamann C, Berges J, Guse E, Wessely A, Weich A, Retzlaff J, Dorrie J, Schaft N, Wiesinger M, Marz J, Schuler-Thurner B, Knorr H, Gupta S, Singh KP, Schuler G, Heppt MV, Koch EAT, van Kleef ND, Freen-van Heeren JJ, Turksma AW, Wolkenhauer O, Hohberger B, Berking C, Bruns H, Vera J. (2024). Gene network-based and ensemble modeling-based selection of tumor-associated antigens with a predicted low risk of tissue damage for targeted immunotherapy. J Immunother Cancer 1210.1136/jitc-2023-008104.
  4. de Jong MME, Fokkema C, Papazian N, Czeti A, Appelman MK, Vermeulen M, van Heusden T, Hoogenboezem RM, van Beek G, Tahri S, Sanders MA, van de Woestijne PC, Gay F, Moreau P, Buttner-Herold M, Bruns H, van Duin M, Broijl A, Sonneveld P, Cupedo T. (2024). An IL-1beta-driven neutrophil-stromal cell axis fosters a BAFF-rich protumor microenvironment in individuals with multiple myeloma. Nat Immunol 25: 820-33. 10.1038/s41590-024-01808-x.
  5. Karl F, Liang C, Bottcher-Loschinski R, Stoll A, Flamann C, Richter S, Lischer C, Volkl S, Jacobs B, Bottcher M, Jitschin R, Bruns H, Fischer T, Holler E, Rosler W, Dandekar T, Mackensen A, Mougiakakos D. (2023). Oxidative DNA damage in reconstituting T cells is associated with relapse and inferior survival after allo-SCT. Blood 141: 1626-39. 10.1182/blood.2022017267.
  6. Mougiakakos D, Bach C, Bottcher M, Beier F, Rohner L, Stoll A, Rehli M, Gebhard C, Lischer C, Eberhardt M, Vera J, Buttner-Herold M, Bitterer K, Balzer H, Leffler M, Jitschin S, Hundemer M, Awwad MHS, Busch M, Stenger S, Volkl S, Schutz C, Kronke J, Mackensen A, Bruns H. (2021). The IKZF1-IRF4/IRF5 Axis Controls Polarization of Myeloma-Associated Macrophages. Cancer Immunol Res 9: 265-78. 10.1158/2326-6066.CIR-20-0555.
  7. Hofbauer D, Mougiakakos D, Broggini L, Zaiss M, Buttner-Herold M, Bach C, Spriewald B, Neumann F, Bisht S, Nolting J, Zeiser R, Hamarsheh S, Eberhardt M, Vera J, Visentin C, De Luca CMG, Moda F, Haskamp S, Flamann C, Bottcher M, Bitterer K, Volkl S, Mackensen A, Ricagno S, Bruns H. (2021). beta(2)-microglobulin triggers NLRP3 inflammasome activation in tumor-associated macrophages to promote multiple myeloma progression. Immunity 54: 1772-87 e9. 10.1016/j.immuni.2021.07.002.
  8. Busch L, Mougiakakos D, Buttner-Herold M, Muller MJ, Volmer DA, Bach C, Fabri M, Bittenbring JT, Neumann F, Boxhammer R, Nolting J, Bisht S, Bottcher M, Jitschin S, Hoffmann MH, Balzer H, Beier F, Gezer D, Dudziak D, Gelse K, Hennig FF, Pallasch CP, Spriewald B, Mackensen A, Bruns H. (2018). Lenalidomide enhances MOR202-dependent macrophage-mediated effector functions via the vitamin D pathway. Leukemia 32: 2445-58. 10.1038/s41375-018-0114-0.
  9. Bruns H, Bottcher M, Qorraj M, Fabri M, Jitschin S, Dindorf J, Busch L, Jitschin R, Mackensen A, Mougiakakos D. (2017). CLL-cell-mediated MDSC induction by exosomal miR-155 transfer is disrupted by vitamin D. Leukemia 31: 985-8. 10.1038/leu.2016.378.
  10. Bruns H, Buttner M, Fabri M, Mougiakakos D, Bittenbring JT, Hoffmann MH, Beier F, Pasemann S, Jitschin R, Hofmann AD, Neumann F, Daniel C, Maurberger A, Kempkes B, Amann K, Mackensen A, Gerbitz A. (2015). Vitamin D-dependent induction of cathelicidin in human macrophages results in cytotoxicity against high-grade B cell lymphoma. Sci Transl Med 7: 282ra47. 10.1126/scitranslmed.aaa3230.

 

PD Dr. rer. nat Katja Dettmer-Wilde

  1. Träger C, Kaiser M, Freudenstein D, Heckscher S, Dettmer K, Oefner PJ, Liebisch G, Hiergeist A, Gessner A, Lee DH, Angstwurm K, Linker RA, Haase S. (2025) A probiotic approach identifies a Treg-centred immunoregulation via modulation of gut microbiota metabolites in people with multiple sclerosis and healthy individuals, EBioMedicine 12:116:105743. doi: 10.1016/j.ebiom.2025.105743
  2. Kohl L, Siddique MNAA, Bodendorfer B, Berger R, Preikschat A, Daniel C, Ölke M, Liebler-Tenorio E, Schulze-Luehrmann J, Mauermeir M, Yang KT, Hayek I, Szperlinski M, Andrack J, Schleicher U, Bozec A, Krönke G, Murray PJ, Wirtz S, Yamamoto M, Schatz V, Jantsch J, Oefner P, Degrandi D, Pfeffer K, Mertens-Scholz K, Rauber S, Bogdan C, Dettmer K, Lührmann A, Lang R. (2023) Macrophages inhibit Coxiella burnetii by the ACOD1-itaconate pathway for containment of Q fever. EMBO Mol Med. 15(2):e15931. doi: 10.15252/emmm.202215931
  3. Mauermeir M, Ölke M, Hayek I, Schulze-Luehrmann J, Dettmer K, Oefner PJ, Berens C, Menge C, Lührmann A. (2023) Bovine blood-derived macrophages are unable to control Coxiella burnetii replication under hypoxic conditions. Front Immunol. 14:960927. doi: 10.3389/fimmu.2023.960927
  4. Frick L, Hinterland L, Renner K, Vogl M, Babl N, Heckscher S, Weigert A, Weiß S, Gläsner J, Berger R, Oefner PJ, Dettmer K, Kreutz M, Schatz V, Jantsch J. (2022) Acidic Microenvironments Found in Cutaneous Leishmania Lesions Curtail NO-Dependent Antiparasitic Macrophage Activity. Front Immunol. 13:789366. doi: 10.3389/fimmu.2022.789366
  5. Berger RS, Wachsmuth CJ, Waldhier MC, Renner-Sattler K, Thomas S, Chaturvedi A, Niller HH, Bumes E, Hau P, Proescholdt M, Gronwald W, Heuser M, Kreutz M, Oefner PJ, Dettmer K. (2021) Lactonization of the Oncometabolite D-2-Hydroxyglutarate Produces a Novel Endogenous Metabolite. Cancers 13(8):1756. doi: 10.3390/cancers13081756.
  6. Sun X, Berger RS, Heinrich P, Marchiq I, Pouyssegur J, Renner K, Oefner PJ, Dettmer K. (2020) Optimized Protocol for the In Situ Derivatization of Glutathione with N-Ethylmaleimide in Cultured Cells and the Simultaneous Determination of Glutathione/Glutathione Disulfide Ratio by HPLC-UV-QTOF-MS. Metabolites 10:292.
  7. Hayek I, Fischer F, Schulze-Luehrmann J, Dettmer K, Sobotta K, Schatz V, Kohl L, Boden K, Lang R, Oefner PJ, Wirtz S, Jantsch J, Lührmann A. (2019). Limitation of TCA-cycle intermediates represents an oxygen-independent nutritional antibacterial effector mechanism of macrophages. Cell Reports 26:3502-3510
  8. Sun X, Paul H, Berger RS, Oefner PJ, Dettmer K. (2019). Quantification and 13C-tracer analysis of total reduced glutathione by HPLC-QTOFMS/MS. Anal Chim Acta 1080:127-137
  9. Heinrich P, Kohler C, Ellmann L, Kuerner P, Spang R, Oefner PJ, Dettmer K. (2018). Correcting for natural isotope abundance and tracer impurity in MS-, MS/MS- and high-resolution-multiple-tracer-data from stable isotope labeling experiments with IsoCorrectoR. Sci Rep. 8(1):17910
  10. Siegert I, Schodel J, Nairz M, Schatz V, Dettmer K, Dick C, Kalucka J, Franke K, Ehrenschwender M, Schley G, Beneke A, Sutter J, Moll M, Hellerbrand C, Wielockx B, Katschinski DM, Lang R, Galy B, Hentze M W, Koivunen P, Oefner PJ, Bogdan C, Weiss G, Willam C and Jantsch J. (2015). Ferritin-mediated iron sequestration stabilizes hypoxia-inducible factor-1alpha upon LPS activation in the presence of ample oxygen. Cell Reports 13: 2048-55.

Dr. Roman Gerlach

  1. Walter S, Schatz V, Petzold J, Schmidt C, Hoffmann S, Jantsch J, Gerlach RG. (2025). O2-dependent incapacitation of the Salmonella pathogenicity island 1 repressor HilE. Front Cell Infect Microbiol 15: 1434254. 10.3389/fcimb.2025.1434254.
  2. Müller F, Taubmann J, Bucci L, Wilhelm A, Bergmann C, Volkl S, Aigner M, Rothe T, Minopoulou I, Tur C, Knitza J, Kharboutli S, Kretschmann S, Vasova I, Spoerl S, Reimann H, Munoz L, Gerlach RG, Schafer S, Grieshaber-Bouyer R, Korganow AS, Farge-Bancel D, Mougiakakos D, Bozec A, Winkler T, Kronke G, Mackensen A, Schett G. (2024). CD19 CAR T-Cell Therapy in Autoimmune Disease – A Case Series with Follow-up. N Engl J Med 390: 687-700. 10.1056/NEJMoa2308917.
  3. Gerlach RG, Wittmann I, Heinrich L, Pinkenburg O, Meyer T, Elpers L, Schmidt C, Hensel M, Schnare M. (2024). Subversion of a family of antimicrobial proteins by Salmonella enterica. Front Cell Infect Microbiol 14: 1375887. 10.3389/fcimb.2024.1375887.
  4. Nüse B, Holland T, Rauh M, Gerlach RG, Mattner J. (2023). L-arginine metabolism as pivotal interface of mutual host-microbe interactions in the gut. Gut Microbes 15: 2222961. 10.1080/19490976.2023.2222961.
  5. Hoffmann S, Walter S, Blume AK, Fuchs S, Schmidt C, Scholz A, Gerlach RG. (2018). High-Throughput Quantification of Bacterial-Cell Interactions Using Virtual Colony Counts. Front Cell Infect Microbiol 8: 43. 10.3389/fcimb.2018.00043.
  6. Wilck N, Matus MG, Kearney SM, Olesen SW, Forslund K, Bartolomaeus H, Haase S, Mahler A, Balogh A, Marko L, Vvedenskaya O, Kleiner FH, Tsvetkov D, Klug L, Costea PI, Sunagawa S, Maier L, Rakova N, Schatz V, Neubert P, Fratzer C, Krannich A, Gollasch M, Grohme DA, Corte-Real BF, Gerlach RG, Basic M, Typas A, Wu C, Titze JM, Jantsch J, Boschmann M, Dechend R, Kleinewietfeld M, Kempa S, Bork P, Linker RA, Alm EJ, Muller DN. (2017). Salt-responsive gut commensal modulates T(H)17 axis and disease. Nature 551: 585-9. 10.1038/nature24628.
  7. Hoffmann S, Schmidt C, Walter S, Bender JK, Gerlach RG. (2017). Scarless deletion of up to seven methyl-accepting chemotaxis genes with an optimized method highlights key function of CheM in Salmonella PLoS One 12: e0172630. 10.1371/journal.pone.0172630.
  8. Gerlach RG, Walter S, McClelland M, Schmidt C, Steglich M, Prager R, Bender JK, Fuchs S, Schoerner C, Rabsch W, Lang W, Jantsch J. (2017). Comparative whole genome analysis of three consecutive Salmonella diarizonae Int J Med Microbiol 307: 542-51. 10.1016/j.ijmm.2017.09.001.
  9. Jennewein J, Matuszak J, Walter S, Felmy B, Gendera K, Schatz V, Nowottny M, Liebsch G, Hensel M, Hardt WD, Gerlach RG, Jantsch J. (2015). Low-oxygen tensions found in Salmonella-infected gut tissue boost Salmonella replication in macrophages by impairing antimicrobial activity and augmenting Salmonella Cell Microbiol 17: 1833-47. 10.1111/cmi.12476.
  10. Wille T, Wagner C, Mittelstädt W, Blank K, Sommer E, Malengo G, Döhler D, Lange A, Sourjik V, Hensel M, Gerlach RG. (2014). SiiA and SiiB are novel type I secretion system subunits controlling SPI4-mediated adhesion of Salmonella enterica. Cell Microbiol 16: 161-78. 10.1111/cmi.12222.

Prof. Dr. med. Jonathan Jantsch

  1. Müller D, Geisberger S., Kleinewietfeld M., Jantsch J.(2023). Salt sensitivity includes effects on immune cell signalling and metabolism. Nat Rev Immunol, 23(6):341-342,
  2. Neubert P, Homann A, Wendelborn D, Bär AL, Krampert L, Trum M, Schröder A, Ebner S, Weichselbaum A, Schatz V, Linz P, Veelken R, Schulte-Schrepping J, Aschenbrenner  AC, Quast T, Kurts C, Geisberger S, Kunzelmann K, Hammer K, Binger KJ, Titze J, Müller DN, Kolanus W, Schultze JL, Wagner S and Jantsch J. (2020). NCX1 represents an ionic Na+ sensing mechanism in macrophages. PLOS Biology, 18:6. doi: 10.1371/journal.pbio.3000722.1
  3. Neubert P, Weichselbaum A, Reitinger C, Schatz V, Schröder A, Ferdinand J, Simon M, Bär AL, Brochhausen C, Gerlach RG, Tomiuk S, Hammer K, Wagner S, van Zandbergen G, Binger KJ, Müller DN, Kitada K, Clatworthy MR, Kurts C, Titze J, Abdullah Z and Jantsch, J. (2019). HIF1A and NFAT5 coordinate Na+-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting. Autophagy, 2019: 1899-1916
  4. Schröder A, Neubert P, Titze J, Bozec A, Neuhofer W, Proff P, Kirschneck C and Jantsch J. (2019). Osteoprotective action of low-salt diet requires myeloid cell-derived NFAT5. JCI Insight, 4(23):e127868. doi: 10.1172/jci.insight.127868
  5. Hayek I, Fischer F, Schulze-Lührmann J, Dettmer K, Sobotta K, Schatz V, Kohl L, Boden K, Lang R, Oefner PJ, Wirtz S, Jantsch J* and Lührmann A* (2019). Limitation of TCA-cycle intermediates represents an oxygen-independent nutritional antibacterial effector mechanism of macrophages. Cell Reports 26: 3502-3510, *shared senior authorship
  6. Schatz V, Strüssmann Y, Mahnke A, Schley G, Waldner M, Ritter U, Wild J, Willam C, Dehne N, Brüne B, McNiff J M, Colegio O R, Bogdan C and Jantsch J. (2016). Myeloid cell-derived HIF-1alpha promotes control of Leishmania major. J Immunol 197: 4034-41.
  7. Siegert I, Schödel J, Nairz M, Schatz V, Dettmer K, Dick C, Kalucka J, Franke K, Ehrenschwender M, Schley G, Beneke A, Sutter J, Moll M, Hellerbrand C, Wielockx B, Katschinski D M, Lang R, Galy B, Hentze M W, Koivunen P, Oefner P J, Bogdan C, Weiss G, Willam C and Jantsch J. (2015). Ferritin-mediated iron sequestration stabilizes hypoxia-inducible factor-1alpha upon LPS activation in the presence of ample oxygen. Cell Reports 13: 2048-55.
  8. Jennewein J, Matuszak J, Walter S, Felmy B, Gendera K, Schatz V, Nowottny M, Liebsch G, Hensel M, Hardt W D, Gerlach R G and Jantsch J.(2015). Low-oxygen tensions found in Salmonella-infected gut tissue boost Salmonella replication in macrophages by impairing antimicrobial activity and augmenting Salmonella virulence. Cell Microbiol 17: 1833-47
  9. Jantsch J, Schatz V, Friedrich D, Schroder A, Kopp C, Siegert I, Maronna A, Wendelborn D, Linz P, Binger K J, Gebhardt M, Heinig M, Neubert P, Fischer F, Teufel S, David J P, Neufert C, Cavallaro A, Rakova N, Kuper C, Beck F X, Neuhofer W, Muller D N, Schuler G, Uder M, Bogdan C, Luft F C and Titze J. (2015). Cutaneous Na+ storage strengthens the antimicrobial barrier function of the skin and boosts macrophage-driven host defense. Cell Metab, 21(3):493-501.
  10. Mahnke A, Meier R J, Schatz V, Hofmann J, Castiglione K, Schleicher U, Wolfbeis O S, Bogdan C and Jantsch J. (2014). Hypoxia in Leishmania major skin lesions impairs the NO-dependent leishmanicidal activity of macrophages. J Invest Dermatol 134: 2339-46.

 

Prof. Dr. rer. nat. Sven Krappmann 

  1. Krappmann S*, Gabl E, Pazen T, Heizmann A, Pöggeler S, Krüger T, Kniemeyer O, Einsiedel J, Gmeiner P, Yu Y, Dyer PS, Baker SE, Nowrousian M. (2025). Identification of an a factor-like pheromone secreted by the heterothallic ascomycete Aspergillus fumigatus. Curr Biol 35: 2414-23. 10.1016/j.cub.2025.03.080. (*lead contact)
  2. Dietschmann A, Schruefer S, Westermann S, Henkel F, Castiglione K, Willebrand R, Adam J, Ruland J, Lang R, Sheppard DC, Esser-von Bieren J, Radtke D, Krappmann S, Voehringer D. (2022). Phosphatidylinositol 3-kinase (PI3K) orchestrates Aspergillus fumigatus-induced eosinophil activation independently of canonical Toll-like receptor (TLR)/C-type lectin receptor (CLR) signaling. mBio 13: e0123922. 10.1128/mbio.01239-22.
  3. Dümig M, Binder J, Gaculenko A, Daul F, Winandy L, Hasenberg M, Gunzer M, Fischer R, Künzler M, Krappmann S. (2021). The infectious propagules of Aspergillus fumigatus are coated with antimicrobial peptides. Cell Microbiol 23: e13301. 10.1111/cmi.13301.
  4. Yu Y, Blachowicz A, Will C, Szewczyk E, Glenn S, Gensberger-Reigl S, Nowrousian M, Wang CCC, Krappmann S. (2018). Mating-type factor-specific regulation of the fumagillin/pseurotin secondary metabolite supercluster in Aspergillus fumigatus. Mol Microbiol 10: 1045-1065. 10.1111/mmi.14136.
  5. Sasse A, Hamer S N, Amich J, Binder J, Krappmann S. (2016). Mutant characterization and in vivo conditional repression identify aromatic amino acid biosynthesis to be essential for Aspergillus fumigatus virulence. Virulence 7: 56-62. 10.1080/21505594.2015.1109766.
  6. Amich J, Schafferer L, Haas H, Krappmann S. (2013). Regulation of sulphur assimilation is essential for virulence and affects iron homeostasis of the human-pathogenic mould Aspergillus fumigatus. PLoS Pathog 9: e1003573. 10.1371/journal.ppat.1003573.
  7. Hartmann T, Cairns T C, Olbermann P, Morschhäuser J, Bignell EM, Krappmann S. (2011). Oligopeptide transport and regulation of extracellular proteolysis are required for growth of Aspergillus fumigatus on complex substrates but not for virulence. Mol Microbiol 82: 917-35. 10.1111/j.1365-2958.2011.07868.x.
  8. Bergmann A, Hartmann T, Cairns T, Bignell EM, Krappmann S. (2009). A regulator of Aspergillus fumigatus extracellular proteolytic activity is dispensable for virulence. Infect Immun 77: 4041-50. 10.1128/IAI.00425-09.
  9. Bayram Ö, Krappmann S, Ni M, Bok JW, Helmstaedt K, Valerius O, Braus-Stromeyer S, Kwon NJ, Keller NP, Yu JH, Braus GH. (2008). VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism. Science 320: 1504-6. 10.1126/science.1155888.
  10. Krappmann S, Sasse C and Braus GH. (2006). Gene targeting in Aspergillus fumigatus by homologous recombination is facilitated in a non-homologous end joining-deficient genetic background. Eukaryot Cell 5: 212-5. 10.1128/EC.5.1.212-215.2006.

 

Dr. rer. nat. Meik Kunz

  1. Fuchs M, Kreutzer F P, Kapsner L A, Mitzka S, Just A, Perbellini F, Terracciano C M, Xiao K, Geffers R, Bogdan C, Prokosch H U, Fiedler J, Thum T* and Kunz M*. Integrative Bioinformatic Analyses of Global Transcriptome Data Decipher Novel Molecular Insights into Cardiac Anti-Fibrotic Therapies. Int J Mol Sci., 2020; 21(13): 4727. (*equally contributing last authors).
  2. Stojanović S D, Fuchs M, Kunz M, Xiao K, Just A, Pich A, Bauersachs J, Fiedler J, Sedding D and Thum T. Inflammatory Drivers of Cardiovascular Disease: Molecular Characterization of Senescent Coronary Vascular Smooth Muscle Cells. Front Physiol., 2020; 11:520.
  3. Stojanović S D, Fuchs M, Fiedler J, Xiao K, Meinecke A, Just A, Pich A, Thum T and Kunz M. Comprehensive Bioinformatics Identifies Key microRNA Players in ATG7-Deficient Lung Fibroblasts. Int J Mol Sci., 2020; 21(11): 4126.
  4. Kunz M*, Wolf B*, Fuchs M*, Christoph J, Xiao K, Thum T, Atlan D, Prokosch H U and Dandekar T. A comprehensive method protocol for annotation and integrated functional understanding of Brief Bioinform., 2020; 21(4): 1391-1396. (*equally contributing first authors).
  5. Kunz M, Jeromin J, Fuchs M, Christoph J, Veronesi G, Flentje M, Nietzer S, Dandekar G and Dandekar T. In silico signalling modeling to understand cancer pathways and treatment responses. Brief Bioinform., 2020; 21(3): 1115-1117.
  6. Baur F*, Nietzer S*, Kunz M*, Saal F*, Jeromin J, Matschos S, Linnebacher M, Walles H, Dandekar T and Dandekar G. (2019). Connecting cancer pathways to tumor engines: A stratification tool for colorectal cancer combining human in vitro tissue models with Boolean in silico Cancers (Basel) 20;12(1). pii: E28. (*equally contributing first authors).
  7. Vey J, Kapsner L A, Fuchs M, Unberath P, Veronesi G and Kunz M. A toolbox for functional analysis and the systematic identification of diagnostic and prognostic gene expression signatures combining meta-analysis and machine learning. (2019). Cancers (Basel) 11(10): 1606.
  8. Göttlich C*, Kunz M*, Zapp C, Nietzer S, Walles H, Dandekar T and Dandekar G. A combined tissue engineered/in silico signature tool for patient stratification in lung cancer. (2018). Mol Oncol 12(8): 1264-1285 (*equally contributing first authors).
  9. Kunz M*, Liang C*, Nilla S, Cecil A and Dandekar T. The drug-minded protein interaction database (DrumPID) for efficient target analysis and drug development. (2016). Database (Oxford) pii: baw041. (*equally contributing first authors).
  10. Viereck J, Kumarswamy R, Foinquinos A, Xiao K, Avramopoulos P, Kunz M, Dittrich M, Maetzig T, Zimmer K, Remke J, Just A, Fendrich J, Scherf K, Bolesani E, Schambach A, Weidemann F, Zweigerdt R, de Windt LJ, Engelhardt S, Dandekar T, Batkai S and Thum T. (2016). Long noncoding RNA Chast promotes cardiac remodeling. Transl Med 8(326): 326ra22.

 

Prof. Dr. rer. nat. Anja Lührmann

  1. Schulze-Luehrmann J, Liebler-Tenorio E, Felipe-Lopez A, Lührmann A. (2024). Cell death induction facilitates egress of Coxiella burnetii from infected host cells at late stages of infection. Mol Microbiol 121: 513-528. 10.1111/mmi.15210.
  2. Kohl L, Siddique MNAA, Bodendorfer B, Berger R, Preikschat A, Daniel C, Ölke M, Liebler-Tenorio E, Schulze-Luehrmann J, Mauermeir M, Yang KT, Hayek I, Szperlinski M, Andrack J, Schleicher U, Bozec A, Krönke G, Murray PJ, Wirtz S, Yamamoto M, Schatz V, Jantsch J, Oefner P, Degrandi D, Pfeffer K, Mertens-Scholz K, Rauber S, Bogdan C, Dettmer K, Lührmann A, Lang R. (2023). Macrophages inhibit Coxiella burnetii by the ACOD1-itaconate pathway for containment of Q fever. EMBO Mol Med. 10.15252/emmm.202215931.
  3. Cordsmeier, Rinkel S, Jeninga M, Schulze-Luehrmann J, Ölke M, Schmid B, Hasler D, Meister G, Häcker G, Petter M, Beare PA, Lührmann A. (2022). The Coxiella burnetii T4SS effector protein AnkG hijacks the 7SK small nuclear ribonucleoprotein complex for reprogramming host cell transcription. PLoS Pathogens. 18(2): e1010266. 1371/journal.ppat.1010266.
  4. Friedrich A, Beare PA, Schulze-Luehrmann J, Cordsmeier A, Pazen T, Sonnewald S, Lührmann A. (2021). The Coxiella burnetii effector protein CaeB modulates endoplasmatic reticulum (ER) stress signalling and is required for efficient replication in Galleria mellonella. Cell Microbiol. 23(4): e13305. 10.1111/cmi.13305.
  5. Hayek I, Fischer F, Schulze-Lührmann J, Dettmer K, Sobotta K, Schatz V, Kohl L, Boden K, Lang R, Oefner PJ, Wirtz S, Jantsch J, Lührmann A. (2019). Limitation of TCA Cycle Intermediates Represents an Oxygen-Independent Nutritional Antibacterial Effector Mechanism of Macrophages. Cell Rep. 26(13):3502-3510.e6. 1016/j.celrep.2019.02.103.
  6. Lührmann A, Newton HJ, Bonazzi M. (2017). Beginning to Understand the Role of the Type IV Secretion System Effector Proteins in Coxiella burnetii Curr Top Microbiol Immunol. 413:243-268. 10.1007/978-3-319-75241-9_10.
  7. Eckart RA, Bisle S, Schulze-Luehrmann J, Wittmann I, Jantsch J, Schmid B, Berens C, Lührmann A. (2014). Antiapoptotic activity of Coxiella burnetii effector protein AnkG is controlled by p32-dependent trafficking. Infect Immun. 82(7):2763-71. 10.1128/IAI.01204-13.
  8. Klingenbeck L, Eckart RA, Berens C, Lührmann A. (2013). The Coxiella burnetii type IV secretion system substrate CaeB inhibits intrinsic apoptosis at the mitochondrial level. Cell Microbiol. 15(4):675-87. 10.1111/cmi.12066.
  9. Lührmann A, Nogueira CV, Carey KL, Roy CR. (2010). Inhibition of pathogen-induced apoptosis by a Coxiella burnetii type IV effector proteins. Proc Natl Acad Sci USA. 107(44):18997-9001. 10.1073/pnas.1004380107.
  10. Pan X, Lührmann A, Satoh A, Laskowski-Arce MA, Roy CR. (2008). Ankyrin repeat proteins comprise a diverse family of bacterial type IV effectors. Science. 320(5883):1651-4. 1126/science.1158160.

 

PD Dr. rer. nat. Michaela Petter

  2. Tang J, Yeoh LM, Grotz MD, Goodman CD, Chisholm SA, Nguyen HHT, Yu C, Pareek K, McPherson F, Cozijnsen A, Hustadt SA, Josling GA, Day KP, Schulz D, McFadden GI, de Koning-Ward TF*, Petter M*, Duffy MF* (2025). PfGCN5 is essential for Plasmodium falciparum survival and transmission and regulates Pf H2B.Z acetylation and chromatin structure. Nucleic Acids Research, 20;53(6):gkaf218. doi: 10.1093/nar/gkaf218. (* shared senior authorship)
  3. Amann M, Warstat R, Rechten KK, Theuer P, Schustereder M, Clavey S, Breit B, Einsle O, Hügle M, Petter M, Günther S (2025). A Novel Inhibitor against the Bromodomain Protein 1 of the Malaria Pathogen Plasmodium Falciparum. ChemMedChem. 18:e2500024. doi: 10.1002/cmdc.202500024.
  4. Azizan S, Selvarajah SA, Tang J, Jeninga MD, Schulz D, Pareek K, Herr T, Day KP, De Koning-Ward TF, Petter M#, Duffy MF# (2023). The P. falciparum alternative histones Pf H2A.Z and Pf H2B.Z are dynamically acetylated and antagonized by PfSir2 histone deacetylases at heterochromatin boundaries. mBio, 26:e0201423. doi: 10.1128/mbio.02014-23 (# shared senior authorship)
  5. Wichers JS, Krumkamp R, Held J, von Thien H, Wittmann I, Ruge JM, Moser K, Dara A, Strauss J, Esen M, Höppner YD, Kremsner PG, Sim BKL, Hoffman SL, Duffy MF, Otto TD, Gilberger TW, Silva JC, Mordmüller B, Petter M, Bachmann A (2023). The exception that proves the rule: Virulence gene expression at the onset of Plasmodium falciparum blood stage infections. PLoS Pathogens, 19(6):e1011468. doi: 10.1371/journal.ppat.1011468
  6. Jeninga MD, Tang J, Selvarajah SA, Maier AG, Duffy MF, Petter M (2023). Plasmodium falciparum gametocytes display global chromatin remodelling during sexual differentiation. BMC Biology, 21:65. doi: 10.1186/s12915-023-01568-4
  7. Quinn JE, Jeninga MD, Limm K, Pareek K, Meißgeier T, Bachmann A, Duffy MF, Petter M (2022). The putative bromodomain protein PfBDP7 of the malaria parasite Plasmodium falciparum cooperates with PfBDP1 in the silencing of variant surface antigen expression. Frontiers Cell Dev Biol, 10:816558. doi: 10.3389/fcell.2022.816558
  8. Bachmann A, Scholz JAM, Janßen M, Retzlaff S, Schmetz C, Klinkert MQ, Tannich E, Bruchhaus I, Petter M (2015). Refining the Localization and Membrane Association of Members of the RIFIN, STEVOR and PfMC-2TM Protein Families in Plasmodium falciparum Infected Erythrocytes. Malaria Journal, 14: 274. doi: 10.1186/s12936-015-0784-2
  9. Josling GA*, Petter M*, Oehring SC, Gupta AP, Dietz O, Wilson DW, Schubert T, Längst G, Gilson PR, Crabb BS, Moes S, Jenoe P, Lim M, Brown GV, Bozdech Z, Voss TS, Duffy MF (2015). A Plasmodium falciparum Bromodomain Protein Regulates Invasion Gene Expression. Cell Host and Microbe, 17 (6): 741-51. doi: 10.1016/j.chom.2015.05.009 (*joint first authorship)
  10. Petter M, Selvarajah SA, Lee CC, Chin WH, Gupte AP, Bozdech Z, Brown GV, Duffy MF (2013). H2A.Z and H2B.Z double-variant nucleosomes define intergenic regions and dynamically occupy var gene promoters in the malaria parasite Plasmodium falciparum. Molecular Microbiology, 87(6):1167-82. doi: 10.1111/mmi.12154
  11. Petter M, Lee CC, Byrne TJ, Boysen KE, Volz J, Ralph SA, Cowman AF, Brown GV, Duffy MF (2011).  Expression of P. falciparum var genes involves exchange of the histone variant H2A.Z at the promoter. PLoS Pathogens, 7 (2):e1001292. doi: 10.1371/journal.ppat.1001292

 

Dr. med. Stefan Uderhardt

  1. Kim JS, Trzebanski S, Shin SH, Schori L, Frumer Friedman GR, Ilani NC, Kadam A, Vicario R, Aust O, Bugaeva P, Piatek S, Ismajli LK, Hoffmann CJ, Scheller M, Boura-Halfon S, Kaushansky N, Golani O, Solomon A, Liu Z, Amann L, Böhm-Sturm P, Koch SP, Wenger N, Netherlands Brain Bank, Ginhoux F, Prinz M, Avraham R, Harms C, Geissmann F, Müller-Tidow C, Uderhardt S, Milenkovic I, Shlush L, Jung S (2025). Clonal hematopoiesis-associated motoric deficits caused by monocyte-derived microglia accumulating in aging mice. Cell Rep. 44(5):115609. doi: 10.1016/j.celrep.2025.115609
  2. Vicanolo T, Özcan A, Li JL, Huerta-López C, Ballesteros I, Rubio-Ponce A, Dumitru AC, Nicolás-Ávila JÁ, Molina-Moreno M, Reyes-Gutierrez P, Johnston AD, Martone C, Greto E, Quílez-Alvarez A, Calvo E, Bonzon-Kulichenko E, Álvarez-Velez R, Chooi MY, Kwok I, González-Bermúdez B, Malleret B, Espinosa FM, Zhang M, Wang YL, Sun D, Zhen Chong S, El-Armouche A, Kim KK, Udalova IA, Greco V, Garcia R, Vázquez J, Dopazo A, Plaza GR, Alegre-Cebollada J, Uderhardt S*, Ng LG*, Hidalgo A* (2025). Matrix-producing neutrophils populate and shield the skin. Nature.1–9. doi: 10.1038/s41586-025-08741-5 * shared senior authors.
  3. Schnitzerlein M, Wegner A, Brahim OB, Blumenthal DB, Zaburdaev V*, Uderhardt S*. Cellular morphodynamics as quantifiers for functional states of resident tissue macrophages in vivo. PLoS Comput Biol. 2025;21(5):e1011859. DOI: 10.1371/journal.pcbi.1011859. * shared senior authors.
  4. Gessain G, Anzali AA, Lerousseau M, Mulder K, Bied M, Auperin A, Stockholm D, Signolle N, Sassi F, Marques Da Costa ME, Marchais A, Sayadi A, Weidner D, Uderhardt S, Blampey Q, Nakkireddy SR, Broutin S, Dutertre CA, Busson P, Walter T, Marhic A, Moya-Plana A, Guerlain J, Breuskin I, Casiraghi O, Gorphe P, Classe M, Scoazec JY, Bleriot C, Ginhoux F (2024). Trem2-expressing multinucleated giant macrophages are a biomarker of good prognosis in head and neck squamous cell carcinoma. Cancer Discov. 10.1158/2159-8290.CD-24-0018
  5. Bucci L, Hagen M, Rothe T, Raimondo MG, Fagni F, Tur C, Wirsching A, Wacker J, Wilhelm A, Auger JP, Pachowsky M, Eckstein M, Alivernini S, Zoli A, Krönke G, Uderhardt S, Bozec A, D’Agostino MA, Schett G, Grieshaber-Bouyer R (2024). Bispecific T cell engager therapy for refractory rheumatoid arthritis. Nat Med. 30(6):1593–601. doi: 10.1038/s41591-024-02964-1
  6. Auger JP, Zimmermann M, Faas M, Stifel U, Chambers D, Krishnacoumar B, Taudte RV, Grund C, Erdmann G, Scholtysek C, Uderhardt S, Ben Brahim O, Pascual Maté M, Stoll C, Böttcher M, Palumbo-Zerr K, Mangan MSJ, Dzamukova M, Kieler M, Hofmann M, Blüml S, Schabbauer G, Mougiakakos D, Sonnewald U, Hartmann F, Simon D, Kleyer A, Grüneboom A, Finotto S, Latz E, Hofmann J, Schett G, Tuckermann J, Krönke G (2024). Metabolic rewiring promotes anti-inflammatory effects of glucocorticoids. Nature. 629(8010):184–92. 10.1038/s41586-024-07282-7
  7. Uderhardt S, Neag G, N Germain R (2023). Dynamic Multiplex Tissue Imaging in Inflammation Research. Annu Rev Pathol. 10.1146/annurev-pathmechdis-070323-124158
  8. Silvin A, Uderhardt S, Piot C, Da Mesquita S, Yang K, Geirsdottir L, Mulder K, Eyal D, Liu Z, Bridlance C, Thion MS, Zhang XM, Kong WT, Deloger M, Fontes V, Weiner A, Ee R, Dress R, Hang JW, Balachander A, Chakarov S, Malleret B, Dunsmore G, Cexus O, Chen J, Garel S, Dutertre CA, Amit I, Kipnis J, Ginhoux F (2022). Dual ontogeny of disease-associated microglia and disease inflammatory macrophages in aging and neurodegeneration. Immunity. 55(8):1448-1465.e6. 10.1016/j.immuni.2022.07.004
  9. Freeman SA*, Uderhardt S*, Saric A, Collins RF, Buckley CM, Mylvaganam S, Boroumand P, Plumb J, Germain RN, Ren D, Grinstein S (2020). Lipid-gated monovalent ion fluxes regulate endocytic traffic and support immune surveillance. Science. 367(6475):301–5. 10.1126/science. aaw9544 * shared first authors
  10. Uderhardt S, Martins AJ, Tsang JS, Lämmermann T, Germain RN (2019). Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage. Cell. 177(3):541-555.e17. 10.1016/j.cell.2019.02.028

 

Prof. Dr. rer. nat. David Vöhringer

  1. Westermann S, Radtke D, Kramer L, Wirtz S, Voehringer D. (2025). Activation of STAT6 in Intestinal Epithelial Cells Predisposes to Gut Inflammation. Eur J Immunol 55: e202451394. 10.1002/eji.202451394.
  2. Schmitt MER, Lutz J, Haase P, Bosl MR, Wienands J, Engels N, Voehringer D. (2020). The B-cell antigen receptor of IgE-switched plasma cells regulates memory IgE responses. J Allergy Clin Immunol 146: 642-51 e5. 10.1016/j.jaci.2020.02.015.
  3. Krljanac B, Schubart C, Naumann R, Wirtz S, Culemann S, Kronke G, Voehringer D. (2019). RELMalpha-expressing macrophages protect against fatal lung damage and reduce parasite burden during helminth infection. Sci Immunol 410.1126/sciimmunol.aau3814.
  4. Schwartz C, Eberle JU, Hoyler T, Diefenbach A, Lechmann M, Voehringer D. (2016). Opposing functions of thymic stromal lymphopoietin-responsive basophils and dendritic cells in a mouse model of atopic dermatitis. J Allergy Clin Immunol 138: 1443-6 e8. 10.1016/j.jaci.2016.04.031.
  5. Turqueti-Neves A, Otte M, Schwartz C, Schmitt ME, Lindner C, Pabst O, Yu P, Voehringer D. (2015). The Extracellular Domains of IgG1 and T Cell-Derived IL-4/IL-13 Are Critical for the Polyclonal Memory IgE Response In Vivo. PLoS Biol 13: e1002290. 10.1371/journal.pbio.1002290.
  6. Schwartz C, Turqueti-Neves A, Hartmann S, Yu P, Nimmerjahn F, Voehringer D. (2014). Basophil-mediated protection against gastrointestinal helminths requires IgE-induced cytokine secretion. Proc Natl Acad Sci U S A 111: E5169-77. 10.1073/pnas.1412663111.
  7. Voehringer D. (2013). Protective and pathological roles of mast cells and basophils. Nat Rev Immunol 13: 362-75. 10.1038/nri3427.
  8. Ohnmacht C, Schwartz C, Panzer M, Schiedewitz I, Naumann R, Voehringer D. (2010). Basophils orchestrate chronic allergic dermatitis and protective immunity against helminths. Immunity 33: 364-74. 10.1016/j.immuni.2010.08.011.
  9. Ohnmacht C, Pullner A, King SB, Drexler I, Meier S, Brocker T, Voehringer D. (2009). Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity. J Exp Med 206: 549-59. 10.1084/jem.20082394.
  10. Huber S, Hoffmann R, Muskens F, Voehringer D. (2010). Alternatively activated macrophages inhibit T-cell proliferation by Stat6-dependent expression of PD-L2. Blood 116: 3311-20. 10.1182/blood-2010-02-271981.

 

PD Dr. rer. nat. Stefan Wirtz

  1. Schmalzl L, Leupold T, Kreiss L, Waldner M, Schürmann S, Neurath MF, Becker and  Wirtz S. (2022). Interferon regulatory factor 1 (IRF-1) promotes intestinal group 3 innate lymphoid responses during Citrobacter rodentium infection. Nat Commun 13(1): 5730. 10.1038/s41467-022-33326-5.
  2. Knipfer L, Schulz-Kuhnt A, Kindermann M, Greif V, Symowski C, Vöhringer D, Neurath M F, Atreya I, and Wirtz S. (2019) A CCL1/CCR8-dependent feed forward mechanism drives ILC2 functions in type 2-mediated inflammation J Exp Med 216:12 2763-2777. 10.1084/jem.201821113.
  3. Wirtz S, Popp V, Kindermann M, Gerlach K, Weigmann B, Fichtner-Feigl S and Neurath M F. (2017). Chemically induced mouse models of acute and chronic intestinal inflammation. Nat Protoc 12: 1295-1309. 10.1038/nprot.2017.0445.
  4. Gunther C, He G W, Kremer A E, Murphy J M, Petrie E J, Amann K, Vandenabeele P, Linkermann A, Poremba C, Schleicher U, Dewitz C, Krautwald S, Neurath M F, Becker C and Wirtz S. (2016). The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis. J Clin Invest 126: 4346-60. 10.1172/JCI87545.
  5. Mahapatro M, Foersch S, Hefele M, He G W, Giner-Ventura E, McHedlidze T, Kindermann M, Vetrano S, Danese S, Gunther C, Neurath M F, Wirtz S* and Becker C*. (2016). Programming of intestinal epithelial differentiation by IL-33 derived from pericryptal fibroblasts in response to systemic infection. Cell Reports 15: 1743-56. * 10.1016/j.celrep.2016.04.049 * shared senior authorship.
  6. McHedlidze T, Kindermann M, Neves A T, Voehringer D, Neurath M F and Wirtz S. (2016). IL-27 suppresses type 2 immune responses in vivo via direct effects on group 2 innate lymphoid cells. Mucosal Immunol 9: 1384-94. 10.1038/mi.2016.209.
  7. McHedlidze T, Waldner M, Zopf S, Walker J, Rankin A L, Schuchmann M, Voehringer D, McKenzie A N, Neurath M F, Pflanz S and Wirtz S. (2013). Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis. Immunity 39: 357-71. 10.1016/j.immuni.2013.07.018.
  8. Wirtz S, Billmeier U, McHedlidze T, Blumberg R S and Neurath M F. (2011). Interleukin-35 mediates mucosal immune responses that protect against T-cell-dependent colitis. Gastroenterology 141: 1875-86. 10.1053/j.gastro.2011.07.040.
  9. Wirtz S, Tubbe I, Galle P R, Schild H J, Birkenbach M, Blumberg R S and Neurath M F. (2006). Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27. J Exp Med 203: 1875-81. 10.1084/jem.20060471.
  10. Wirtz S, Galle P R and Neurath M F. (1999). Efficient gene delivery to the inflamed colon by local administration of recombinant adenoviruses with normal or modified fibre structure. Gut 44: 800-7. 10.1084/jem.20060471.

 

Prof. Dr. Vasily Zaburdaev

  1. Chai L, Zaburdaev V, Kolter R. (2024). How bacteria actively use passive physics to make biofilms. Proc Natl Acad Sci USA (PNAS) 121 (40) e2403842121
  2. Pancholi A, Klingberg T, Zhang W, Prizak R, Mamontova I, Noa A, Sobucki M, Kobitski AYu, Nienhaus GU*, Zaburdaev V*, and Hilbert L*. (2021). RNA polymerase II clusters form in line with surface condensation on regulatory chromatin. Mol Syst Biol 17: e10272 (2021) (*shared corresponding author). https://doi.org/10.15252/msb.202110272
  3. Hilbert L, Sato Y, Kuznetsova K, Bianucci T, Kimura H, Jülicher F, Honigmann A, Zaburdaev V*, and Vastenhouw NL*. (2021). Transcription organizes euchromatin via microphase separation. Nat Commun 12:1360 (*shared supervision).
  4. Kuan HS, Pönisch W, Jülicher F, and Zaburdaev V. (2021). Continuum Theory of Active Phase Separation in Cellular Aggregates. Phys Rev Lett 126:018102.
  5. Pönisch W, Eckenrode K B, Alzurqa K, Nasrollahi H, Weber C, Zaburdaev V*, and Biais N*. (2018). Pili mediated intercellular forces shape heterogeneous bacterial microcolonies prior to multicellular differentiation. Sci Rep 8(1):16567 (*shared corresponding author).
  6. Pönisch W, Weber CA, Juckeland G, Biais N, and Zaburdaev V. (2017). Multiscale modeling of bacterial colonies: how pili mediate the dynamics of single cells and cellular aggregates.  New J Phys 19:015003. https://doi.org/10.1088/1367-2630/aa5483
  7. Zaburdaev V, Denisov S, and Klafter J. (2015). Lévy walks. Rev Mod Phys 87:483-530 (2015). https://doi.org/10.1103/RevModPhys.87.483
  8. Zaburdaev V, Biais N, Schmiedeberg M, Eriksson J, Jonsson AB, Sheetz MP, and Weitz DA. (2014). Uncovering the mechanism of trapping and cell orientation during Neisseria gonorrhoeae twitching motility. Biophys J 107: 1523-1531 (2014).
  9. Wilking J N, Zaburdaev V, De Volder M, Losick R, Brenner MP and Weitz DA. (2013). Liquid transport facilitated by channels in Bacillus subtilis biofilms.Proc Natl Acad Sci USA 110:848-852 (2013). https://doi.org/10.1073/pnas.1216376110
  10. Zaburdaev V, Uppaluri S, Pfohl T, Engstler M, Friedrich R and Stark H. Langevin dynamics deciphers the motility pattern of swimming parasites. Phys Rev Lett 106(20): 208103 (2011). https://doi.org/10.1103/PhysRevLett.106.208103

 

Prof. Dr. rer. nat. Mario M. Zaiss

  1. Dürholz K, Ehnes L, Linnerbauer M, Schmid E, Danzer H, Schmidt M, Lößlein L, Amend L, Frech M, Azizov V, Schälter F, Gessner A, Lucas S, Lesker T, Taudte V, Hofmann J, Beyer F, Bootz-Maoz H, Reich Y, Romano H, Mauro D, Beckervordersandforth R, Kragsnaes M, Torkell E, Xiang W, Haghikia A, Akdis C, Ciccia F, Bäuerle T, Sarter K, Strowig T, Yissachar N, Schett G, Rothhammer V, Zaiss MM. (2025) Gut-specific histamine 3 receptor signaling orchestrates microglia-dependent resolution of peripheral inflammation. J Clin Invest 135(18):e184697. doi: 10.1172/JCI184697.
  2. Schälter F, Frech M, Durholz K, Lucas S, Sarter K, Lebon L, Esser-von Bieren J, Dubey LK, Voehringer D, Schett G, Harris NL, Zaiss MM. (2022). Acetate, a metabolic product of Heligmosomoides polygyrus, facilitates intestinal epithelial barrier breakdown in a FFAR2-dependent manner. Int J Parasitol 52: 591-601. 1016/j.ijpara.2022.04.004.
  3. Moyat M, Lebon L, Perdijk O, Wickramasinghe LC, Zaiss MM, Mosconi I, Volpe B, Guenat N, Shah K, Coakley G, Bouchery T, Harris NL. (2022). Microbial regulation of intestinal motility provides resistance against helminth infection. Mucosal Immunol 15: 1283-95. 1038/s41385-022-00498-8.
  4. Azizov V, Dietel K, Steffen F, Durholz K, Meidenbauer J, Lucas S, Frech M, Omata Y, Tajik N, Knipfer L, Kolenbrander A, Seubert S, Lapuente D, Sokolova MV, Hofmann J, Tenbusch M, Ramming A, Steffen U, Nimmerjahn F, Linker R, Wirtz S, Herrmann M, Temchura V, Sarter K, Schett G, Zaiss MM. (2020). Ethanol consumption inhibits T(FH) cell responses and the development of autoimmune arthritis. Nat Commun 11: 1998. 1038/s41467-020-15855-z.
  5. Rapin A, Chuat A, Lebon L, Zaiss MM, Marsland BJ, Harris NL. (2020). Infection with a small intestinal helminth, Heligmosomoides polygyrus bakeri, consistently alters microbial communities throughout the murine small and large intestine. Int J Parasitol 50: 35-46. 35-46. 10.1016/j.ijpara.2019.09.005.
  6. Tajik N, Frech M, Schulz O, Schalter F, Lucas S, Azizov V, Durholz K, Steffen F, Omata Y, Rings A, Bertog M, Rizzo A, Iljazovic A, Basic M, Kleyer A, Culemann S, Kronke G, Luo Y, Uberla K, Gaipl US, Frey B, Strowig T, Sarter K, Bischoff SC, Wirtz S, Canete JD, Ciccia F, Schett G, Zaiss MM. (2020). Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis. Nat Commun 11: 1995. 1038/s41467-020-15831-7.
  7. Lucas S, Omata Y, Hofmann J, Bottcher M, Iljazovic A, Sarter K, Albrecht O, Schulz O, Krishnacoumar B, Kronke G, Herrmann M, Mougiakakos D, Strowig T, Schett G, Zaiss MM. (2018). Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss. Nat Commun 9: 55. 1038/s41467-017-02490-4.
  8. Zaiss MM, Harris NL. (2016). Interactions between the intestinal microbiome and helminth parasites. Parasite Immunol 38: 5-11. 5-11. 10.1111/pim.12274.
  9. Zaiss MM, Rapin A, Lebon L, Dubey LK, Mosconi I, Sarter K, Piersigilli A, Menin L, Walker AW, Rougemont J, Paerewijck O, Geldhof P, McCoy KD, Macpherson AJ, Croese J, Giacomin PR, Loukas A, Junt T, Marsland BJ, Harris NL. (2015). The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation. Immunity 43: 998-1010. 1371/journal.ppat.1003531.
  10. Zaiss MM, Maslowski KM, Mosconi I, Guenat N, Marsland BJ, Harris NL. (2013). IL-1beta suppresses innate IL-25 and IL-33 production and maintains helminth chronicity. PLoS Pathog 9: e1003531. 1371/journal.ppat.1003531.